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    <div class="container">
        
        <div class="docTitle">
            <h3>肿瘤个体化诊疗基因检测</h3>
            <h4>Precision Oncology ＆ Personalized Treatment</h4>
            
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        <div class="common-role">
            <section class="display-bt">
                <div class="leftPart">
                    项目名称：
                </div>
                <div class="rightPart">
                    泛癌种基因检测
                </div>
            </section>
            <section class="display-bt">
                <div class="leftPart">
                    患者姓名：
                </div>
                <div class="rightPart">
                    吴显恩
                </div>
            </section>
            <section class="display-bt">
                <div class="leftPart">
                    样本编号：
                </div>
                <div class="rightPart">
                    36985593
                </div>
            </section>
            <section class="display-bt">
                <div class="leftPart">
                    送检医院：
                </div>
                <div class="rightPart">
                    
                </div>
            </section>
            <section class="display-bt">
                <div class="leftPart">
                    收样日期：
                </div>
                <div class="rightPart">
                    2020/7/04
                </div>
            </section>
            
            <section class="display-bt">
                <div class="leftPart">
                    报告日期：
                </div>
                <div class="rightPart">
                    2020/7/04
                </div>
            </section>
            
            
        
        </div>
        <!-- <div class="tab1-common">
            <table border="1">
                <tr>
                    <th>项目名称：</th>
                    <th>泛癌种基因检测</th>
                </tr>
                <tr>
                    <th>患者姓名：</th>
                    <th>吴显恩 </th>
                </tr>
                <tr>
                    <th>样本编号：</th>
                    <th>36985593 </th>
                </tr>
                <tr>
                    <th>送检医院：</th>
                    <th></th>
                </tr>
                <tr>
                    <th>收样日期：</th>
                    <th>2020/7/04</th>
                </tr>
                <tr>
                    <th>报告日期：</th>
                    <th>2020/7/04</th>
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            </table>
        </div> -->

        <div class="main-content">
             
            <section class="main-part part0">

                <h2 style="text-align: center;">目 &nbsp;  &nbsp;录</h2>
                <div class="display-aw mulu">
                    <div style="width: 47%; text-align: right;">

                        <h3 style="position: relative;"> <a href="#m1">靶向治疗提示</a>  <img src="./img/680/mulu.png" style="vertical-align: bottom;position: absolute;right: -40px;" alt=""> </h3>
                        <p style="font-size: 14px;"> <a href="#m1-1">各驱动变异循证医学证据</a> </p>
                        <p style="font-size: 14px;"><a href="#m1-2">靶向治疗解读说明</a></p>
                    </div>
                    <div style="width: 50%; text-align: left;">

                    </div>
                </div>
                <div class="display-aw mulu">
                    <div style="width: 47%; text-align: right;">

                    </div>
                    <div style="width: 47%; text-align: left;">

                        <h3 style="position: relative;"><img src="./img/680/mulu.png" style="vertical-align: bottom;position: absolute;left: -40px;" alt=""> <a href="#m2">免疫治疗提示</a>   </h3>
                        <p style="font-size: 14px;"><a href="#m2-1">MSI微卫星不稳定检测结果</a></p>
                        <p style="font-size: 14px;"><a href="#m2-2">TMB肿瘤突变负荷检测结果</a> </p>
                        <p style="font-size: 14px;"><a href="#m2-3">DDR基因（DNA损伤修复反应基因）检测结果</a> </p>
                        <p style="font-size: 14px;"><a href="#m2-4">免疫治疗敏感驱动突变检测结果</a> </p>
                        <p style="font-size: 14px;"><a href="#m2-5">免疫治疗耐药驱动突变检测结果</a> </p>
                        <p style="font-size: 14px;"><a href="#m2-6">免疫治疗超进展相关基因检测结果</a> </p>
                        <p style="font-size: 14px;"><a href="#m2-7">HLA分型检测结果</a> </p>
                        <p style="font-size: 14px;"><a href="#m2-8">肿瘤新抗原检测结果</a> </p>
                        <p style="font-size: 14px;"><a href="#m2-9">免疫治疗解读说明</a> </p>
                        
                    </div>
                </div>
                <div class="display-aw mulu">
                    <div style="width: 47%; text-align: right;">

                        <h3 style="position: relative;"> <a href="#m3">化学治疗提示</a>  <img src="./img/680/mulu.png" style="vertical-align: bottom;position: absolute;right: -40px;" alt=""> </h3>
                      
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                    <div style="width: 50%; text-align: left;">

                    </div>
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                <div class="display-aw mulu">
                    <div style="width: 47%; text-align: right;">

                    </div>
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                        <h3 style="position: relative;"><img src="./img/680/mulu.png" style="vertical-align: bottom;position: absolute;left: -40px;" alt=""> <a href="#m4">肿瘤遗传性检测结果</a>   </h3>
                     
                        
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                <div class="display-aw mulu">
                    <div style="width: 47%; text-align: right;">

                        <h3 style="position: relative;"> <a href="#m5">基因突变检测结果汇总</a>  <img src="./img/680/mulu.png" style="vertical-align: bottom;position: absolute;right: -40px;" alt=""> </h3>
                        <p style="font-size: 14px;"> <a href="#m5-1">体细胞突变</a> </p>
                        <p style="font-size: 14px;"><a href="#m5-3">遗传性肿瘤、HRD、DDR相关基因胚系突变</a></p>
                        <p style="font-size: 14px;"> <a href="#m5-3">重点基因拷贝数检测结果</a> </p>
                        <p style="font-size: 14px;"> <a href="#m5-3">基因融合检测结果</a> </p>
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                    <div style="width: 50%; text-align: left;">

                    </div>
                </div>
                <div class="display-aw mulu">
                    <div style="width: 47%; text-align: right;">

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                    <div style="width: 47%; text-align: left;">

                        <h3 style="position: relative;"><img src="./img/680/mulu.png" style="vertical-align: bottom;position: absolute;left: -40px;" alt=""> <a href="#m6">附录</a>   </h3>
                     
                        
                    </div>
                </div>
            </section>

            <div class="main-table tab2-680">
                <ul>
                    <li>
                        <div class="tab-title">受检者信息和样本信息</div> 
                    </li>
                    <li style="border-right: 1px solid #ccc;">
                        <span style="width: 11%;">姓名：</span><text style="width: 11%;">z</text>
                        <span style="width: 11%;">性别：</span><text style="width: 11%;">n</text>
                        <span style="width: 11%;">年龄：</span><text style="width: 11%;">18</text>
                        <span style="width: 11%;">医院：</span><text style="width: 22%;">同济</text>
                    </li>
                    <li style="border-right: 1px solid #ccc;">
                        <span style="width: 11%;">病理诊断:</span><text style="width: 33.3%;">肺癌</text>
                        <span style="width: 22.4%;">既往靶向/免疫用药方案:</span><text style="width: 33%;">123</text>
                    </li>
                    <li style="border-right: 1px solid #ccc;">
                        <span style="width: 11%;">样本编号:</span><text style="width: 22%;">0014</text>
                        <span style="width: 11.3%;">组织来源:</span><text style="width: 22%;">原发病灶</text>
                        <span style="width: 11%;">样本类型:</span><text style="width: 22%;">石蜡切片</text>
                    </li>
                    <li style="border-right: 1px solid #ccc;">
                        <span style="width: 11%;">取样日期:</span><text style="width: 22%;">2020.12.13</text>
                        <span style="width: 11.3%;">送检日期:</span><text style="width: 22%;">2012.12.32</text>
                        <span style="width: 11%;">报告日期:</span><text style="width: 22%;">2012.21.3</text>
                    </li>
                </ul>
                <div class="fuzhu">附注：以上受检者信息和样本信息均为患者送检时提供的信息，本检测不对这些内容进行判读或解读。</div>
            </div>
            <!-- <div class="main-table tab3-680">
                <ul>
                    <li>
                        <div class="tab-title" id="m1">靶向治疗提示</div> 
                    </li>
                    <li style="background:rgba(182, 232, 219, 1)">
                        <text style='width: 11%;'>基因</text> <text style='width:25%'>检测结果(突变丰度)</text> <text  style='width:63%'>可能获益的治疗方式</text>
                    </li>
                    <li class='hight80' style="border-right: 1px solid #ccc;">
                        <text style='width: 11%;'>EGFR</text> 
                        <text style='width:25%'>Exon 21 L858R（11.76%）</text> 
                        <text style='width:63%'><span>奥西替尼 <sup>A</sup> </span><span>阿法替尼<sup>A</sup></span><span> 达克替尼<sup>A</sup></span> <span> 吉非替尼<sup>A</sup> </span><span> 厄洛替尼<sup>A</sup> <br></span><span> 埃克替尼<sup>A</sup></span>
                        </text>
                    </li>
                    <li class='hight80' style="border-right: 1px solid #ccc;">
                        <text style='width: 11%;'>TP53</text> 
                        <text style='width:25%'>Exon 6 R196G（11.27%）</text> 
                        <text style='width:63%'><span class='lightSpan'>AZD1775 <sup>C</sup> </span><span class='lightSpan'>APR-246 <sup>C</sup> </span>
                        </text>
                    </li>
                    <li class='hight80' style="border-right: 1px solid #ccc;">
                        <text style='width: 11%;'>CTNNB1</text> 
                        <text style='width:25%'>Exon 3 S37C（3.41%）</text> 
                        <text style='width:63%'><span class='lightSpan'>伊马替尼 <sup>C</sup> </span><span class='lightSpan'>美洛昔康 <sup>C</sup> </span><span class='lightSpan'>塞来昔布 <sup>C</sup> </span><span class='lightSpan'>依维莫司 <sup>C</sup> </span><span class='lightSpan'>替西罗莫司 <sup>C</sup> </span>
                        </text>
                    </li>
                    <li class='hight80' style="border-right: 1px solid #ccc;">
                        <text style='width: 11%;'>HR通路相关基因</text> 
                        <text style='width:25%'>未发现致病突变</text> 
                        <text style='width:63%'>无
                        </text>
                    </li>
                </ul>
            </div> -->


            <div class="table-680-1" style="width: 100%;margin-top: 1000px;">
                <table border="1" style="width: 100%;">
                    <tr style="line-height: 40px;color: #fff;background: rgba(62,175,150,1);">
                        <th colspan="3">靶向治疗提示</th>
                    </tr>
                    
                    <tr style="text-align: center;line-height: 40px;">
                        <th style="width: 10%;">基因</th>
                        <th style="width: 30%;">检测结果(突变丰度)</th>
                        <th style="width: 60%;">可能获益的治疗方式</th>
                    </tr>
                    <tr style="text-align: center;">
                        <td>EGFR</td>
                        <td>Exon 21 L858R（11.76%）</td>
                        <td>
                            <span class="bgB1">奥西替尼 <sup>A</sup> </span><span class="bgB1">阿法替尼<sup>A</sup></span><span class="bgB1"> 达克替尼<sup>A</sup></span> <span class="bgB1"> 吉非替尼<sup>A</sup> </span><span class="bgB1"> 厄洛替尼<sup>A</sup> <br></span><span class="bgB1"> 埃克替尼<sup>A</sup></span>
                        </td>
                    </tr>
                    <tr style="text-align: center;">
                        <td>TP53</td>
                        <td>Exon 6 R196G（11.27%）</td>
                        <td>
                            <span class='lightSpan'>AZD1775 <sup>C</sup> </span><span class='lightSpan'>APR-246 <sup>C</sup> </span> 
                        </td>
                    </tr>
                    <tr style="text-align: center;">
                        <td>CTNNB1</td>
                        <td>Exon 3 S37C（3.41%）</td>
                        <td>
                            <span class='lightSpan'>伊马替尼 <sup>C</sup> </span><span class='lightSpan'>美洛昔康 <sup>C</sup> </span><span class='lightSpan'>塞来昔布 <sup>C</sup> </span><span class='lightSpan'>依维莫司 <sup>C</sup> </span><span class='lightSpan'>替西罗莫司 <sup>C</sup> </span>
                        </td>
                    </tr>
                    <tr style="text-align: center;">
                        <td>HR通路相关基因</td>
                        <td>未发现致病突变</td>
                        <td>无</td>
                    </tr>
                </table>
            </div>
            <div class="main-table tab4-680" style="margin-top: 1000px;">
                <ul>
                    <li>
                        <div class="tab-title">免疫治疗提示（PD1等免疫检查点抑制剂治疗）</div> 
                    </li>
                    <li style="background:rgba(182, 232, 219, 1)">
                        <text style='width: 20%;'>检测指标</text> <text style='width:79%'>检测结果</text> 
                    </li>
                    <li>
                        <text style='width: 20%;'>MSI</text> <text style='width:79%'>MSS微卫星稳定</text> 
                    </li>
                    <li style="background:rgba(0, 124, 200, 1)">
                        <text style='width: 20%;'>TMB</text> <text style='width:79%'>TMB肿瘤突变负荷高 （25.58个突变/Mb）(A级)</text> 
                    </li>
                    <li>
                        <text style='width: 20%;'>DDR</text> <text style='width:79%'>DDR基因无变异</text> 
                    </li>
                    <li>
                        <text style='width: 20%;'>免疫敏感驱动基因</text> <text style='width:79%'>免疫治疗敏感驱动基因无变异</text> 
                    </li>
                    <li style="background:rgba(233, 233, 233, 1)">
                        <text style='width: 20%;'>免疫耐药驱动基因</text> <text style='width:79%'>免疫治疗耐药驱动相关EGFR基因发生激活突变等(C级)</text> 
                    </li>
                    <li>
                        <text style='width: 20%;'>免疫超进展</text> <text style='width:79%'>免疫治疗超进展相关基因无变异</text> 
                    </li>
                    <li>
                        <text style='width: 20%;'>HLA分型</text> <text style='width:79%'>HLA分型结果中发现A、B、C三个等位基因均为杂合状态</text> 
                    </li>
                </ul>
            </div>
            <div class="main-table tab5-680" style="margin-top: 500px;">
                <ul>
                    <li>
                        <div class="tab-title">化学治疗提示</div> 
                    </li>
                    <li style="background:rgba(150, 215, 235, 1)">
                        <text style='width: 100%;'>可能有效且毒副作用低的药物：铂类, 顺铂, 卡铂, 奥沙利铂, 顺铂联合紫杉醇, 环磷酰胺联合表柔比星</text>
                    </li>
                  
                    <li style="border-right: 1px solid #ccc;">
                        <text style="width:11%">样本编号：</text><text style='width:38%'>001</text> <text style="width:11%">报告日期：</text><text style='width:38%'>001</text>
                    </li>
                </ul>
            </div>
            <div class="main-table tab6-680" style="margin-top: 1000px;">
                <ul>
                    <li>
                        <div class="tab-title">肿瘤遗传性检测结果</div> 
                    </li>
                    <li >
                        <text style='width: 100%;'>在42种遗传性肿瘤综合征相关的162个基因中，未发现与遗传性肿瘤相关的明确致病突变位点</text>
                    </li>
                  
                </ul>
                <div class="fuzhu">附注： 以上靶向、免疫、化学和最新研究进展治疗提示部分与后面附录信息遵循A、B、C、D四个证据等级以及对应颜色标识。</div>
            </div>
            <div class="main-table tab7-680">
                <ul>
                    
                    <li >
                        <span style="width: 3%; background:rgba(0,124,200)">A</span><text style="width: 16%;">FDA/NCCN推荐药物</text>
                        <span style="width: 3%; background:rgba(90,184,218)">B</span><text style="width: 16%;">专家共识药物</text>
                        <span style="width: 3%; background:rgba(150,215,235)">C</span><text style="width: 16%;">临床证据药物</text>
                        <span style="width: 3%; background:rgba(191,232,243)">D</span><text style="width: 16%;">临床前证据药物</text>
                        <text style="width: 16%;font-weight: 600;">提示可能有效</text>
                    </li>
                    <li>
                        <span style="width: 3%; background:rgba(255,255,255)">&nbsp;</span><text style="width: 16%;font-weight: 600;">提示可能无效</text>
                        <span style="width: 3%; background:#ccc">&nbsp;</span><text style="width: 16%;font-weight: 600;">提示可能耐药</text>
                    </li>
                  
                </ul>
                
            </div>
            <div class="main-table tab8-680" style="margin-top: 1000px;">
                <ul>
                    <li>
                        <div class="tab-title">关于检测项目</div> 
                    </li>
                    <li style="height:auto">
                        <text style='width: 100%;'>本检测基于第二代测序技术，捕获680个与癌症发生发展的生物学原理及个性化治疗方案高度相关的基因的重要外显子及部分内含子区域，以及其他50个基因在实体肿瘤中高发突变的热点区域，进行高深度测序，测量这些基因中出现的来自组织或循环肿瘤DNA的突变、重排、拷贝数增加等变异事件，从而对靶向、免疫、化学或其他可能的治疗方式根据证据等级进行提示。</text>
                    </li>
                    <li>
                        <text style='width: 100%;'>相关局限性说明：由于肿瘤异质性等原因，本检测报告仅对本样本负责，患者诊疗决策需在临床医生指导下进行</text>
                    </li>
                  
                </ul>
               
            </div>
            <div class="main-table tab9-680">
                <ul>
                    <li>
                        <div class="tab-title">样本和数据质控信息</div> 
                    </li>
                    <li style="height:auto">
                        <text style='width: 100%;'>DNA总量为1689ng，符合检测标准。</text>
                    </li>
                    <li>
                        <text style='width: 100%;'>本次检测的平均有效测序深度为2202.6X，符合检测标准。</text>
                    </li>
                    <li style="">
                        <span style="width: 12%;">测序操作人:</span><text style="width: 21%;">X</text>
                        <span style="width: 12%;">数据分析人:</span><text style="width: 21%;">Y</text>
                        <span style="width: 12%;">报告审核人:</span><text style="width: 21%;">Z</text>
                        
                    </li>
                    <li style="">
                        <span style="width: 11%;">样本编号:</span><text style="width: 38%;">0014</text>
                        <span style="width: 11%;">报告日期:</span><text style="width: 38%;">2020.12.12</text>
                        
                    </li>
                </ul>
               
            </div>

            <section class="main-part part1">
                <div class="des">
                    <p>说明：报告中采用统一颜色标识对基因突变信息进行标注，其中：</p>
                    <div style="line-height: 50px;border: 1px solid #ccc;">
                        <span style="text-align: center;display: inline-block;width:80px;background:red;color: white;" >红色</span> <text>表示明确致病突变位点</text>
                        <span style="text-align: center;display: inline-block;width:80px;background:rgb(255,139,139);color: white;">浅红色</span> <text>表示未明意义突变位点</text>
                    </div>
                </div>
                <h2 style="margin-top: 500px;">一、靶向治疗提示</h2>
                <p style="font-size:22px;font-weight: bold;">本次检测共找到3个驱动基因的变异事件：EGFR L858R、TP53 R196G和CTNNB1 S37C。非小细胞肺癌常见癌种驱动基因检测结果说明:</p>
            
                <div class="table-680-1" style="width: 100%;">
                    <table border="1" style="width: 100%;">
                            
                          <tr style="text-align: center;line-height: 30px;">
                              <td> <span style="background:red;color: white;">EGFR突变</span> </td>
                              <td>KRAS未发生突变</td>
                              <td>BRAF未发生突变</td>
                              <td>HER2未发生突变</td>
                          </tr>
                          <tr style="text-align: center;line-height: 30px;">
                            <td> ALK未发生融合</td>
                            <td>ROS1未发生融合</td>
                            <td>RET未发生融合</td>
                            <td>MET未发生扩增</td>
                        </tr>
                        <tr style="text-align: center;line-height: 30px;">
                            <td> MET exon 14 skipping 未发生</td>
                            <td>NTRK1未发生融合</td>
                            <td>NTRK2未发生融合</td>
                            <td>NTRK3未发生融合</td>
                        </tr>
                    </table>

                    <p style="font-size:16px">注：驱动变异是靶向治疗提示的基础和前提条件，此处仅呈现通过数据库、文献等各方面数据和规则判断为驱动突变的肿瘤变异事件。</p>
                </div>

                <h4 id="m1-1">  ·  该驱动变异关键突变循证医学证据</h4>

                <div class="bannerTitle">驱动变异1: EGFR( L858R，突变丰度11.76%)</div>
            
                <h4>  ·  该基因临床治疗说明</h4>

                <h5 style="font-weight: bold;">EGFR 原癌基因</h5>
                <p style="line-height:24px">
                    EGFR是一种酪氨酸激酶受体，在肺癌和脑癌等癌症中，EGFR通过扩增和/或突变而发生改变。
                    表皮生长因子受体(EGFR)是由EGF家族细胞外配体激活的跨膜受体(PMID: 24691965)。EGFR是ErbB受体家族的成员之一，包括ERBB2、ERBB3、ERBB4受体。绑定的表皮生长因子受体配体,包括表皮生长因子配体和转化生长因子α(TGFα),激活下游信号通路包括规范化MAPK和PI3K / AKT / mTOR信号级联(PMID: 22239438)。EGFR可以与ErbB家族的其他成员进行同型二聚或异型二聚启动信号(PMID: 25621509)。egfr介导的信号激活最终导致细胞增殖、迁移和分化(PMID: 18045542)。虽然EGFR通常在正常成人组织中表达水平较低，但这种受体通过体细胞突变和/或EGFR基因的扩增而过度激活，在许多类型的癌症如肺癌、脑癌、结直肠癌和头颈癌中都可以发现(PMID: 10880430, 17318210)。在肺癌中，EGFR突变的激活导致了一种对EGFR酪氨酸激酶抑制敏感的受体组成激活形式(PMID: 15329413)。针对EGFR的酪氨酸激酶抑制剂，包括阿法替尼、厄洛替尼和吉非替尼，已经被批准用于非小细胞肺癌患者的一线治疗(PMID: 14977817, 24868098, 26039556, 25963089)。EGFR的第二位点耐药突变可以发生在以前用这些抑制剂治疗过的癌症中(PMID: 29068003)。Osimertinib是一种二线酪氨酸激酶抑制剂，已获得FDA批准，用于EGFR耐药突变为T790M、L858R和19外子缺失的非小细胞肺癌复发患者(PMID: 27923840)。此外，EGFR基因的拷贝数扩增导致几种癌症类型的受体过表达，包括脑癌和结肠直肠癌，这些癌症也可能对EGFR抑制敏感(PMID: 11426640)。
                </p>
                <div class="bannerTitle" style="margin-top: 500px;">驱动变异2: TP53( R196G，突变丰度11.27%)</div>
            
                <h4>  ·  该驱动变异关键循证医学证据</h4>
                <div class="table-680-2" style="width: 100%;">
                    <table border="1" style="width: 100%;">
                            <tr style="line-height:30px;background:rgb(233,233,233)">

                                <th style="width:25%;">生物标志物</th>
                                <th style="width:37%;">药物</th>
                                <th style="width:38%;">证据类型</th>
                            </tr>

                            <tr style="line-height:30px;text-align:center;">
                                <td>TP53 突变</td>
                                <td>AZD1775( C)</td>
                                <td>卵巢癌;Responsive (Support)</td>
                            </tr>
                            <tr>
                                <td style="background:rgb(233,233,233)">证据描述</td>
                                <td colspan="2" style="padding:2px">
                                    AZD1775是WEE1的选择性抑制剂，在临床前模型中对p53缺陷型肿瘤具有化学增强作用。在一项I期研究中，AZD1775与卡铂联合使用的最大耐受剂量证明了靶标的参与。该研究对患有p53抑癌基因（TP53）突变的卵巢癌难治性或耐药性（<3个月）一线铂类治疗的患者进行了II期研究，以确定总体缓解率，无进展皮肤活检中的总生存期，药代动力学和磷酸化细胞周期蛋白依赖性激酶（CDK1）的调节。患者和方法在每个21天的周期内，患者每隔2.5天每天两次接受卡铂（曲线下面积，5 mg / mL·min）联合AZD1775 225 mg口服治疗，直至疾病进展。结果AZD1775加卡铂显示出可控的毒性；最常见的不良反应是疲劳（87％），恶心（78％），血小板减少症（70％），腹泻（70％）和呕吐（48％）。最常见的3级或4级不良事件是血小板减少症（48％）和中性粒细胞减少症（37％）。在入组的24例患者中，有21例可评估疗效终点​​。总体缓解率为43％（95％CI，22％至66％），包括一名完全缓解时间较长的患者（5％）。中位无进展和总生存时间分别为5.3个月（95％CI，2.3至9.0个月）和12.6个月（95％CI，4.9至19.7），到数据截止，其中两名患者在2011年的反应持续时间超过31和42个月。结论据我们所知，这是第一份提供AZD1775增强TP53突变肿瘤中卡铂疗效的临床证据的报告展。 (PMID: 27998224  )
                                </td>
                            </tr>
                       
                    </table>

                    <table border="1" style="width: 100%;">
                        <tr style="line-height:30px;background:rgb(233,233,233)">

                            <th style="width:25%;">生物标志物</th>
                            <th style="width:37%;">药物</th>
                            <th style="width:38%;">证据类型</th>
                        </tr>

                        <tr style="line-height:30px;text-align:center;">
                            <td>TP53 突变</td>
                            <td>APR-246 ( C)</td>
                            <td>卵巢癌;Responsive (Support)</td>
                        </tr>
                        <tr>
                            <td style="background:rgb(233,233,233)">证据描述</td>
                            <td colspan="2" style="padding:10px">
                                APR-246 是 p53 蛋白激活剂，能够恢复 p53 蛋白的正常功能，从而有效的诱导肿瘤细胞死亡，还能克服其他抗肿瘤药物的耐药性，对 p53 失活或突变的患者有效，主要靶向 R273、 R175、 R248，临床Ⅰ期试验效果良好（NCT00900614）。一项 Ib 期临床试验，招募肿瘤标本检出 P53 IHC 染色突变的复发性高级别浆液性卵巢癌（HGSOC）患者给予 APR-246 和卡铂（C），脂质体阿霉素（PLD）治疗。结果表明， APR-246 主要毒性事件是头晕（71%，20/28），但 24 小时可以得到解决 。RECIST1.1 评估的 20 例患者中 3 例出现 CR，9 例PR（4 例待确诊），8 例 SD，0 例 PD。总体响应率（GCIG 或 RECIST）为 74%（17/23）。 APR-246（67.5 mg/kg）与 C 和 PLD 联合治疗可用于后续 2期试验  。（Journal of Clinical Oncology 34, no. 15_suppl (May 20, 2016) 5571-5571.）。 
                            </td>
                        </tr>
                   
                    </table>

                
                </div>
                
                <h4>  ·    该基因临床治疗说明</h4>
                <h5 style="font-weight: bold;">TP53 抑癌基因</h5>
                <p style="line-height:20px">
                    TP53是DNA损伤通路中的抑癌基因，是癌症中最常见的突变基因。
                    TP53编码p53抑癌蛋白，这是一种转录因子，通过诱导下游的抗肿瘤反应，如DNA修复和凋亡，对细胞压力(包括DNA损伤和致癌激活)做出反应(PMID: 11099028)。TP53是人类癌症中最常见的突变基因，在Li-Fraumeni癌症易感性综合征中发生了种系突变(PMID: 22713868, 21765642)。p53蛋白由一个n端反激活域、一个中心dna结合域、一个寡聚域和一个c端调控域组成(PMID: 22713868)。

                </p>
                <div class="bannerTitle">驱动变异3: CTNNB1( S37C，突变丰度3.41%)</div>


                <h5 style="font-weight: bold;">该驱动变异关键循证医学证据</h5>
                <div class="table-680-2" style="width: 100%;">
                    <table border="1" style="width: 100%;">
                        <tr style="line-height:40px;background:rgb(233,233,233)">

                            <th style="width:25%;">生物标志物</th>
                            <th style="width:37%;">药物</th>
                            <th style="width:38%;">证据类型</th>
                        </tr>

                        <tr style="line-height:40px;text-align:center;">
                            <td>CTNNB1 致癌突变</td>
                            <td>伊马替尼 ( C )</td>
                            <td>卵巢癌;Responsive (Support)</td>
                        </tr>
                        <tr>
                            <td style="background:rgb(233,233,233)">证据描述</td>
                            <td colspan="2" style="padding:10px">
                                在回顾性分析中，与使用格列卫（伊马替尼）治疗的CTNNB1野生型肿瘤患者相比，携带CTNNB1外显子3激活突变的硬纤维瘤病患者在6个月时表现出更大的进展停滞率。(PMID: 26861905)
                            </td>
                        </tr>
                
                    </table>


                    <table border="1" style="width: 100%;">
                        <tr style="line-height:40px;background:rgb(233,233,233)">

                            <th style="width:25%;">生物标志物</th>
                            <th style="width:37%;">药物</th>
                            <th style="width:38%;">证据类型</th>
                        </tr>

                        <tr style="line-height:40px;text-align:center;">
                            <td>CTNNB1 致癌突变（S45F除外）</td>
                            <td>美洛昔康 ( C )</td>
                            <td>纤维瘤病(Support)</td>
                        </tr>
                        <tr>
                            <td style="background:rgb(233,233,233)">证据描述</td>
                            <td colspan="2" style="padding:10px">
                                33例结缔组织纤维瘤病患者采用COX-2选择性抑制剂美洛昔康治疗，其中，完全缓解（CR）1例，部分缓解7例（PR），12例稳定病情（SD），13例进展（PD）。33例中有21例（64%）存在以下3个点突变：T41A（16例）、S45F（4例）和S45P（1例）。在T41A患者中，16例患者中有11例（CR、PR或SD）有临床获益，包括PR病例。4例S45F突变均表现出较强的β-catenin核表达。S45F突变与不良反应显著相关（所有病例；PD）（p=0.017）(PMID: 24788118)
                            </td>
                        </tr>
                
                    </table>

                    <table border="1" style="width: 100%;">
                        <tr style="line-height:40px;background:rgb(233,233,233)">

                            <th style="width:25%;">生物标志物</th>
                            <th style="width:37%;">药物</th>
                            <th style="width:38%;">证据类型</th>
                        </tr>

                        <tr style="line-height:40px;text-align:center;">
                            <td>CTNNB1 致癌突变</td>
                            <td>塞来昔布 ( C )</td>
                            <td>纤维瘤病(Support)</td>
                        </tr>
                        <tr>
                            <td style="background:rgb(233,233,233)">证据描述</td>
                            <td colspan="2" style="padding:10px">
                                一名39岁男子，右侧第五肋骨和第六肋骨之间有软组织肿块。切除整个肿块，根据组织病理学证实为侵袭性纤维化。术后4个月，MRI显示手术区有软组织肿块，活检证实局部复发。因此，采用放射治疗，但FDG-PET仍能使肿瘤保持活动状态。遗传检测报告CTNNB1基因上存在p.T41A突变。塞来昔布应用后肿瘤迅速恢复。在20个月的随访期内，患者出现明显的退行性改变，无任何症状和体征。(PMID: 28881160)
                            </td>
                        </tr>
                
                    </table>

                    <table border="1" style="width: 100%;">
                        <tr style="line-height:40px;background:rgb(233,233,233)">

                            <th style="width:25%;">生物标志物</th>
                            <th style="width:37%;">药物</th>
                            <th style="width:38%;">证据类型</th>
                        </tr>

                        <tr style="line-height:40px;text-align:center;">
                            <td>CTNNB1 致癌突变</td>
                            <td>依维莫司 ( C )</td>
                            <td>子宫内膜癌(Support)</td>
                        </tr>
                        <tr>
                            <td style="background:rgb(233,233,233)">证据描述</td>
                            <td colspan="2" style="padding:5px">
                                在25例分析了CTNNB1基因的子宫内膜癌患者中发现，依维莫司联合来曲唑治疗CTNNB1突变患者的临床获益率为80%（5例患者，其中3例CR，1例SD）而不具备具有CTNNB1突变
                                的患者临床获益率为35%（20例患者，其中5例CR，1例PR，1例SD）。(PMID: 28881160)
                            </td>
                        </tr>
                
                    </table>

                    <table border="1" style="width: 100%;margin-top: 100px;">
                        <tr style="line-height:40px;background:rgb(233,233,233)">

                            <th style="width:25%;">生物标志物</th>
                            <th style="width:37%;">药物</th>
                            <th style="width:38%;">证据类型</th>
                        </tr>

                        <tr style="line-height:40px;text-align:center;">
                            <td>CTNNB1 致癌突变</td>
                            <td>替西罗莫司 ( C )</td>
                            <td>子宫内膜癌(Support)</td>
                        </tr>
                        <tr>
                            <td style="background:rgb(233,233,233)">证据描述</td>
                            <td colspan="2" style="padding:10px">
                                在一项二期临床试验的回顾性研究中，替西罗莫司治疗增加了存在CTNNB1突变晚期子宫内膜癌患者的无进展生存率（HR 0.46），但反应率没有差异（反应差异0.00）。(PMID: 27016228)
                            </td>
                        </tr>
                
                    </table>
                </div>

                <h4>  ·   该基因临床治疗说明</h4>
                <h4 style="font-weight: bold;">CTNNB1 原癌基因</h4>
                <p style="font-size: 14px;">CTNNB1(β-catenin),循环转录激活因子,在各种癌症突变包括子宫内膜癌和肝细胞癌。</p>
                <p style="font-size: 14px;">CTNNB1编码蛋白质β-catenin,转录激活参与WNT信号通路(PMID: 22682243、22617422)。在缺乏WNT配体,β-catenin隐藏在细胞溶质的交互与APC /轴蛋白破坏复杂。这种破坏复杂包括GSK3β,激酶磷酸化的负责关键β-catenin残留物和定位β-catenin退化。订婚WNT WNT受体的配体导致干扰APC /轴蛋白破坏复杂,释放β-catenin转运到细胞核以及调节目标基因与转录因子激活的TCF /中位数的家庭。重要的转录目标β-catenin / TCF包括细胞周期蛋白D1和MYC (PMID: 10201372、9727977)。β-catenin也会影响信息粘附和细胞迁移(PMID: 15001769)。功能体细胞突变β-catenin CTNNB1导致异常积累的蛋白质和多种实体肿瘤中普遍存在,包括子宫/子宫内膜癌(PMID: 9721853、23636398),卵巢(PMID: 19349352、20942669),肝细胞癌(PMID: 22634756、23788652),和结直肠癌(PMID: 22810696),等等。CTNNB1突变的癌症被假定是抵抗药物抑制WNT通路的上游组件,而不需要直接抑制β-catenin函数(PMID: 19351922、22682243)。</p>
                
                <div class="table-680-3" style="width: 100%;">
                    <table border="1" style="width: 100%;">
                        <tr style="line-height: 30px;color: #fff;background: rgb(62,175,150);">
                            <th colspan="8">HR通路相关基因未发现明确致病突变</th>
                        </tr>
                        <tr style="line-height: 30px;;text-align: center;">
                            <td>BRCA1</td>
                            <td>BRCA2</td>
                            <td>ATM</td>
                            <td>ATR</td>
                            <td>ATRX</td>
                            <td>NBN</td>
                            <td>PALB2</td>
                            <td>RAD50</td>
                        </tr>
                        <tr style="line-height: 30px;;text-align: center;">
                            <td>BARD1</td>
                            <td>BLM</td>
                            <td>BRIP1</td>
                            <td>CHEK1</td>
                            <td>CHEK2</td>
                            <td>RAD51C</td>
                            <td>RAD51D</td>
                            <td>RAD52</td>
                        </tr>
                        <tr style="line-height: 30px;;text-align: center;">
                            <td>FANCA</td>
                            <td>FANCC</td>
                            <td>FANCD2</td>
                            <td>FANCE</td>
                            <td>FANCF</td>
                            <td>RAD51</td>
                            <td>RAD51B</td>
                            <td>BAP1</td>
                        </tr>
                        <tr style="line-height: 30px;;text-align: center;">
                            <td>FANCG</td>
                            <td>FANCI</td>
                            <td>FANCL</td>
                            <td>FANCM</td>
                            <td>MRE11A</td>
                            <td>RAD54L</td>
                            <td>RPA1</td>
                            <td>WRN</td>
                        </tr>
                    </table>
                </div>

                <h4>  ·   检测意义</h4>
                <p style="font-size: 14px;">
                    在临床试验中，NOVA研究中发现，在铂类敏感的复发高级别卵巢癌中，HRD评分高的患者，PARP抑制剂niraparib治疗组相比安慰剂组，PFS为12.9m vs 3.8m（PMID：27717299）。然而，HRD评分并非总能预测PARP抑制剂治疗效果，今年ASCO上报道的GeparOLA研究发现，HRD评分高、BRCA1/2突变的早期乳腺癌患者中，奥拉帕尼组与化疗组（卡铂联合紫杉醇）疗效类似，（pCR率55.1% vs 48.6%（2019 ASCO abstract 506）。
                </p>
            

                <h4 id="m1-2" style="margin-top: 500px;"> 靶向治疗解读说明</h4>
                <h4> ·   靶向治疗与驱动基因</h4>
                <p style="font-size: 14px;">
                
                    靶向治疗药物是针对特定的肿瘤发生发展相关特定基因设计的药物。传统化疗主要针对快速分裂的细胞，既杀伤肿瘤细胞、又杀伤</p>
                    正常细胞，毒副作用大，而靶向治疗更精准的针对肿瘤特定特征或者肿瘤微环境，所以毒副作用相对较低。
                    实际临床应用中，靶向药初步可以分成针对肿瘤抗血管生成及多靶点相关的靶向药和针对肿瘤细胞特定基因变异的靶向药。抗血管生成及多靶点相关的靶向药现阶段大多没有特定的基因变异可以预测其疗效。针对肿瘤细胞特定基因变异的靶向药，一般情况下仅对该类突变患者有效。此类特定基因，包含在肿瘤驱动基因范畴中。
                </p>

                <h4> ·  驱动基因及突变形式说明</h4>
                <h5 style="font-weight: bold;">a. 驱动基因说明</h5>
                <p style="font-size: 14px;">
                    在肿瘤发生发展中扮演重要角色，能够“驱动”癌症疾病进程的基因称为驱动基因。乘客基因则是指对肿瘤发生发展重要性不高的基因，但是，重要性目前只是一个相对概念而不是绝对概念，所以，虽目前有多种方式进行驱动基因的鉴定，但是并没有统一的完整标准。驱动基因又分成发生激活突变后具有促进癌症发生发展的原癌基因和功能正常情况下抑制癌症发生的抑癌基因。驱动基因上的基因变异，可以是驱动突变，也可以是乘客突变。驱动突变可以是原癌基因的激活突变，也可以是抑癌基因的失活突变。一般情况下，肿瘤靶向治疗针对驱动基因中的原癌基因激活突变进行抑制，如EGFR Tkis抑制EGFR突变，或者针对抑癌基因的失活突变进行相关信号通路的协同致死，如PARP抑制剂治疗BRCA1、2基因变异肿瘤。
                </p>

                <h5 style="font-weight: bold;">b. 原癌基因和激活突变</h5>
                <p style="font-size: 14px;">
                    原癌基因指正常功能情况下，在细胞信号传导等多个层面扮演重要角色，但是发生激活突变后会促进癌症发生发展的基因。激活突变一般情况下发生在原癌基因经常发生突变的热点位置上，如下图的PIK3CA和IDH1基因，且突变以错义突变为主。
                </p>

                <h5 style="font-weight: bold;">c. 抑癌基因和失活突变</h5>
                <p style="font-size: 14px;">
                    抑癌基因指正常功能下，扮演着DNA修复等抑制癌症发生发展过程的基因。抑癌基因发生失活突变会导致身体抑制癌症的功能降低。抑癌突变一般情况下热点突变较少，可发生在基因近乎任何区域，如下图的RB1和VHL基因，且会出现更多的截断突变。
                </p>
                <div class="imgBox">
                    <img src="./img/680/img1.png" alt="" style="width: 1000px;height: 232px;">
                </div>

                <h4> ·  肿瘤数据解读证据级别说明</h4>
                <p style="font-size: 14px;">
                    通过二代测序技术，特别是本报告采用的组学检测技术，每个肿瘤患者会找到几十个、几百个甚至于几千个肿瘤基因变异。不同基因变异具有不同的临床指导意义。美国临床肿瘤协会（ASCO）、美国病理学家联合学会会（CAP）和分子病理协会（AMP）共同发布了相关的标准和指南。该指南首先把变异根据临床意义等级分成四类：等级Ⅰ，强临床意义的变异；等级Ⅱ，潜在临床意义的变异；等级Ⅲ，不清楚临床意义的变异；等级Ⅳ，良性和可能良性的变异。其中，又根据变异的证据级别，等级Ⅰ和等级Ⅱ的变异进一
                    步细化分成Level A、B、C、D四个级别。
                    <br>Level A：1、针对某一特定癌症，经过FDA批准的；2，针对某一特定癌种，专业指南推荐的；
                    <br>Level B：基于高水平研究，相关领域专家意见一致；
                    <br>Level C：1、同一分子标志物，FDA批准用于其他癌症；2、作为临床试验纳入标准
                    <br>Level D：临床前研究，结果不确定
     
                </p>

                <h4> ·  肿瘤解读数据库相关说明</h4>
                <h5 style="font-weight: bold;">a. CIVic数据库证据呈现 <img src="./img/680/sm1.png" alt="" style="width: 80px;vertical-align: bottom;margin-left: 20px;"></h5>
                <p style="font-size: 14px;">
                    CIVic是一个基于开放用户提供内容，领域专家进行审核的精准医疗知识社区。领域专家在社区中起着至关重要的作用。领域专家通常是科学家或医生，具有高级学位（PHD或MD级），并展示了与癌症精确医学知识相关的专长（发表记录）。该社区的知识库将变异分成五类：A级，已验证，已批准或者已形成共识；B级，临床证据，来源于临床试验证据或者其他患者来源证据支持；C级：案例研究，来源于临床的案例报道；D级：临床前证据，体内或体外生物学支持证据；E级：非直接证据。
                </p>

                <h5 style="font-weight: bold;">b. Oncokb数据库证据呈现 <img src="./img/680/sm2.png" alt="" style="width: 80px;vertical-align: bottom;margin-left: 20px;"></h5>
                <p style="font-size: 14px;">
                    OncoKB是一个肿瘤精准医学数据库，包含特定的癌症基因变异效应和治疗提示的信息。这是由Memorial Sloan Kettering癌症中心（MSK）的MarieJosée和Henry R. Kravis分子肿瘤学中心的知识系统小组与Quest Diagnostics合作开发和维护的。由MSK的临床人员、研究人员和教学人员共同组成的协作网络进行专家手工注释，OncoKB包含有关477种癌症基因特定变异的详细信息。这些信息具有各种来源，如FDA，NCCN或ASCO等指南，和ClinicalTrials.gov和科学文献等。对于每一种变异，该数据库均会专家手工注释生物学效应、患病率、预后信息和治疗影响。治疗信息使用自行开发的证据级别系统进行分类。该证据级别共分为四类：FDA批准、专家共识、强有力临床证据和强有力生物学证据四种，其分类与ASCO、AMP和CAP共同发布的指南一一对应。
                </p>

                <h5 style="font-weight: bold;">c. CGI数据库证据呈现 <img src="./img/680/sm3.png" alt="" style="width: 80px;vertical-align: bottom;margin-left: 20px;"></h5>
                <p style="font-size: 14px;">
                    CGI(癌症基因组解释器)被设计用于识别驱动肿瘤发展，可能可治疗的变异。CGI依赖于多个数据源和计算机算法，依照不同的证据级别对变异进行分类。这是一个由巴塞罗那生物医学基因组实验室维护开发的一个癌症基因组注释工具。该注释工具相关的数据库大致将变异分为以下五类：临床指南、晚期临床试验、早期临床试验、临床案例报道和临床前数据这五类。由于人类知识积累有限，大部分基因变异是否为致癌变异均是未知的。该注释工具的核心特色是一个针对未知是否致癌的变异进行致癌性预测的工具，oncodriverMUT。该工具结合了大规模肿瘤基因组数据（来自28个癌种的6792个样本）和大规模正常人基因组数据（60706个未经选择的正常人样本）中突变的分布，并结合突变功能预测的多种规则，对未知变异的致癌性进行预测。未知突变经预测，分类为预测为驱动突变级别1、预测为驱动突变级别2和预测为乘客突变。
                        通过对1077已知致癌变异、2819个癌症易感变异、241个癌症基因上已知为良性的PAM（影响蛋白功能突变）和1006个癌症基因上经常出现在一般人群中的PAM的验证，发现该算法的准确性为0.91。
                </p>
                <div class="imgBox">
                    <img src="./img/680/img2.png" alt="" style="width: 800px;">
                    <img src="./img/680/img3.png" alt="" style="width: 800px;margin-top: 40px;">
                </div>
            </section>

            <section class="main-part part2">

                <h2 id="m2">二、免疫治疗提示</h2>
                <p style="font-weight: bold;">
                    本次检测显示该患者MSS微卫星稳定、肿瘤突变负荷TMB高（25.58个突变/Mb）、DDR基因无变异、免疫治疗敏感驱动基因无变异、免疫治疗耐药驱动相关EGFR基因发生激活突变合并CTNNB1基因发生激活突变、免疫治疗超进展相关基因无变异、HLA分型结果中发现A、B、C三个等位基因均为杂合状态。
                </p>
                <h4 id="m2-1">MSI微卫星不稳定检测结果</h4>
                <div class="imgBox">
                    <div >  ·MSS微卫星稳定</div>
                    <div style="font-weight: bold;line-height: 40px;"> PD1等免疫检查点抑制剂可能效果不显著</div>
                    <img src="./img/680/img4.png" alt="" style="width: 600px;">
                    <div style="font-size: 14px;color: #999999;">注：肿瘤组织单样本分析的模式</div>
                </div>


                <h4>· 结果说明</h4>
                <p style="font-size: 14px;">
                    MSI是指与正常组织相比，在肿瘤中某一微卫星由于重复单位的插入或缺失而造成的微卫星长度的任何改变，出现新的微卫星等位基因现象。其发生机制主要包括DNA多聚酶的滑动导致重复序列中1个或多个碱基的错配和微卫星重组导致碱基对的缺失或插入。该结果采用经FDA批准的MSIsensor算法获得。本次检测采用肿瘤组织-正常样本配对分析的模式，共分析了581个微卫星位点，其中15个微卫星位点为具有显著差异的体细胞变异点，比例为2.58%，即MSIsensor评分为2.58。研究表明，MSIsensor评分免疫治疗疗效正相关，也与错义突变和插入缺失突变总量显著正相关（PMID:31048490）。
                </p>

                <h4>· 检测意义</h4>
                <p style="font-size: 14px;">
                    目前FDA批准Pembrolizumab用于dMMR/MSI-H型的转移性实体瘤，Nivolumab用于dMMR/MSI-H的转移性结直肠癌。Science发表了NCT01876511的临床研究结果显示，Pembrolizumab用于治疗MSI-H的晚期肿瘤患者，MSI-H型肿瘤患者ORR高达54%。MSI-H在结直肠癌、胃癌、子宫内膜癌中较多，其他多种癌种都有一定量的分布。MSI是MMR（错配修复系统）的一个反映标志，MMR是人体细胞DNA修复的一种方式之一，MMR缺陷导致DNA出错的概率大规模提升，进而导致该类型肿瘤细胞具有非常高的突变量，而高的突变负荷进一步导致肿瘤细胞高概率采用PD1等通路的免疫逃逸机制。因此，PD1抗体对MSI-H/dMMR肿瘤更可能有效。
                </p>

                <h4 id="m2-2">TMB肿瘤突变负荷检测结果</h4>

                <div class="table-680-1" style="width: 100%;">
                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 30px;">
                            <th> ·肿瘤突变负荷TMB高（25.58个突变/Mb）</th>
                        </tr>
                        <tr style="line-height: 30px;background: rgb(0,124,200);color: #fff;text-align: center;">
                            <td> PD1等免疫检查点抑制剂治疗可能有效（A）</td>
                        </tr>
                    </table>
                </div>

                <h4>· 结果说明</h4>
                <p style="font-size: 14px;">
                    该结果通过680个基因的panel获得，该panel实际大小为2.4M，核算CDS区域为1.29M。TMB肿瘤突变负荷指平均每M（兆）
                    区域，肿瘤细胞发生的非同义突变的个数。（证据级别说明：常规以10个突变/Mb标准时非小细胞肺癌证据级别为B级，结直肠癌和胰腺癌由于免疫治疗有效率低，常规阈值为20，其他所有癌种均为C级；当TMB大于20，高于绝大多数情况阈值时，非小细胞肺癌更新为A级，其他癌种（结直肠癌和胰腺癌除外）更新为B级。
                </p>

                <h4>· 检测意义</h4>
                <p style="font-size: 14px;">
                    TMB在多项临床研究中均被证明能够有效区分PD1抗体、CTLA4抗体等免疫检查点抑制剂治疗是否有效的人群。综合型研究表明，在不同肿瘤中，不同患者的PD1抗体治疗有效性的差异55%可以由TMB的差异解释。TMB是不同肿瘤间体细胞突变量的评估。一般情况下，TMB越高，该肿瘤可能会拥有更多的肿瘤新生抗原，该肿瘤也越有可能在经过免疫检查点抑制剂解除肿瘤免疫逃逸之后，被患者自身的免疫系统所识别，相关治疗在该患者身上也就越可能有效。
                </p>

                <h4 id='m2-3'>DDR基因（DNA损伤修复反应基因）检测结果</h4>
                <div  class="table-680-1" style="width: 100%;">
                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 30px;">
                            <th> · DDR基因无变异</th>
                        </tr>
                        <tr style="line-height: 30px;color: #fff;text-align: center;font-weight: bold;">
                            <td>  PD1等免疫检查点抑制剂等免疫治疗可能不显著</td>
                        </tr>
                    </table>

                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 30px;text-align: center;">
                            <td style="font-weight: bold;background: rgb(233,233,233);">同源重组修复基因</td>
                            <td>BRCA1</td>
                            <td>MRE11A</td>
                            <td>NBN</td>
                            <td>RAD50</td>
                            <td>RAD51</td>
                            <td>RAD51B</td>
                            <td>RAD51D</td>
                            <td>RAD52</td>
                            <td>RAD54L</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td style="font-weight: bold;background: rgb(233,233,233);">范可尼贫血通路基因</td>
                            <td>BRCA2</td>
                            <td>BRIP1</td>
                            <td>FANCA</td>
                            <td>FANCC</td>
                            <td>PALB2</td>
                            <td>RAD51C</td>
                            <td>BLM</td>
                            <td></td>
                            <td></td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td style="font-weight: bold;background: rgb(233,233,233);">碱基切除修复基因</td>
                            <td>ERCC2</td>
                            <td>ERCC3</td>
                            <td>ERCC4</td>
                            <td>ERCC5</td>
                            <td>ERCC6</td>
                            <td></td>
                            <td></td>
                            <td></td>
                            <td></td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td style="font-weight: bold;background: rgb(233,233,233);">错配修复基因</td>
                            <td>MLH1</td>
                            <td>MSH2</td>
                            <td>MSH6</td>
                            <td>PMS1</td>
                            <td>PMS2</td>
                            <td></td>
                            <td></td>
                            <td></td>
                            <td></td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td style="font-weight: bold;background: rgb(233,233,233);">细胞周期检查点基因</td>
                            <td>ATM</td>
                            <td>ATR</td>
                            <td>CHEK1</td>
                            <td>CHEK2</td>
                            <td>MDC1</td>
                            <td></td>
                            <td></td>
                            <td></td>
                            <td></td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td style="font-weight: bold;background: rgb(233,233,233);">其他基因</td>
                            <td>POLE</td>
                            <td>MUTYH</td>
                            <td>PARP1</td>
                            <td>RECQL4</td>
                            <td>BAP1</td>
                            <td></td>
                            <td></td>
                            <td></td>
                            <td></td>
                        </tr>
                    </table>
                </div>
                <h4> · 结果说明</h4>
                <p style="font-size: 14px;">
                    DDR基因突变患者更可能从免疫检查点抑制剂治疗中获益。细胞内正常的代谢活动与环境因素均会引起DNA损伤，初步估算，每个正常细胞每天产生1000-1000000处分子损伤。肿瘤细胞由于基因组等异常，大部分情况下DNA损伤的速率远高于正常细胞。DNA损伤反应基因主要包括错配修复、同源重组修复等DNA修复相关基因（DDR基因），也包括细胞周期检查点、染色质重塑等其他基因，据一篇专家手工注释研究表明，DDR基因大约有450个。DNA损伤反应跟免疫系统之间具有非同寻常的关系，如召集免疫细胞聚集，对T细胞杀伤更敏感等。以上是根据目前最新研究，将已有证据证明相关基因突变与免疫检查点疗效直接相关的DDR基因子集。该基因列表可能会随着DDR基因的研究进展逐步扩大。
                </p>

                <h4> ·相关循证医学证据：</h4>

                <div class="bDetail">
                    <div>泌尿上皮癌</div>
                    <section>
                        <h4>DDR基因明确致病突变泌尿上皮癌患者PD1抗体治疗反应率为80%，意义未明突变患者有效率为54%（2018《JCO》）</h4>
                        <p>60例泌尿上皮癌患者入组相关PD1抗体治疗前瞻性临床实验。DDR基因（共34个基因）突变患者28例（47%），其中明确致病突变患者15例（25%）。出现任意DDR基因突变的患者与更高的治疗反应率相关(67.9% v 18.8%; P＜0.001)。 其中明确致病突变患者治疗反应率为80%，意义不明突变患者有效率为54%，显著高于DDR基因野生型患者（19%，P＜0.001）(PMID：29489427)</p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>非小细胞肺癌</div>
                    <section>
                        <h4>468例NSCLC患者研究发现DDR基因明确致病突变患者ICIs治疗ORR、PFS和OS均显著高于野生型患者（2019 Asco）</h4>
                        <p>
                            468例接受ICIs治疗和NGS检测的NSCLC患者中，242例患者DDR基因发生变异，其中74例定义为DDR阳性(DDR基因致病突变，分别为ATM(41.9%)、MLH1/MSH2/MSH6(18.9%)、BRCA1/2(16.2%)、CHEK1/2(9.4%)、FANC基因(9.4%)、BAP1(5.4%)、RAD基因(5.4%)、ERCC4/6(4.0%)、POLE(2.7%)、ATR(2.7%)，DDR阳性组的TMB中位值明显高于DDR阴性组(12.1 vs 9.8突变/MG, P = 0.007)。各组间PD-L1中位肿瘤比例评分差异无统计学意义(30% vs 25%， P = 0.33)。DDR阳性组(N = 394)相比DDR阴性组有明显高于客观缓解率(31.1%比19.1%,P = 0.03)、更长的平均无进展生存(4.3 vs 2.6个月, P = 0.02)和总生存期(16.3 vs 9.8个月, P = 0.009)。(2019 ASCO abstract 9077)
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>前列腺癌</div>
                    <section>
                        <h4>15例前列腺癌患者研究发现DDR基因明突变患者ICIs治疗PFS均显著高于野生型患者（2019 Asco）</h4>
                        <p>
                            在一项包含15例AR-V7阳性的前列腺癌前瞻性2期临床试验发现，6例患者出现DDR基因突变（3例BRCA2、2例ATm和1例ERCC4，明确致病突变和预测致病突变），DDR阳性组和阴性组在PFS水平具有显著差异。（ PFS (HR 0.31; P=0.01, 显著)， PSA-PFS (HR 0.19; P＜0.01, 显著, PSA 反应 (33% vs. 0%; P=0.14, 非显著), ORR (40% vs. 0%; P=0.46,非显著)), , and OS (HR 0.41; P=0.11, 非显著)）（PMID:29983880 ）
                        </p>
                    </section>
                </div>

                <h4 id="m2-4"> 免疫治疗敏感驱动突变检测结果</h4>
                <div  class="table-680-1" style="width: 100%;">
                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 30px;">
                            <th> · 免疫治疗敏感驱动基因无变异</th>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;font-weight: bold;">
                            <td>   PD1等免疫检查点抑制剂可能效果不显著</td>
                        </tr>
                    </table>

                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 25px;text-align: center;">
                            <td> PDL1/2基因未扩增</td>
                            <td> POLE/POLD1基因无热点突变</td>
                            <td> CDK12基因未发生失活变异</td>
                        </tr>
                        <tr style="line-height: 25px;text-align: center;">
                            <td>TP53合并KRAS突变未发生</td>
                            <td> TP53合并ATM突变未发生</td>
                            <td> PBRM1基因未发生失活变异</td>
                        </tr>
                        <tr style="line-height: 25px;text-align: center;">
                            <td>SERPINB3/4基因未发生突变</td>
                            <td> TET1基因未发生突变</td>
                            <td> </td>
                        </tr>
                       
                    </table>

                    

                </div>

                <h4>  ·结果说明</h4>
                <p style="font-size: 14px;">多种肿瘤驱动基因变异状态与免疫检查点治疗疗效密切相关，且通过迥然不同的作用机制导致对免疫检查点治疗敏感。PDL1/2（该基因位于9p24.1，该区域同时具有PDL2和JAK2基因）扩增主要用肿瘤细胞内生性的PDL1/2高表达相关。既往研究发现，实体瘤中PDL1扩增是极其罕见的事件，发生率大约是0.7%，虽然目前仅少量案例报道，但是其有效率高达66.7%。同时，发病机制类似的霍奇金淋巴瘤是PD1治疗有效率最高（＞70%）的肿瘤类型，同样具有9p24.1扩增。POLE/POLD1是DNA聚合酶的亚基，均具有核酸外切酶结构域。热点突变与超高突变负荷相关，同事与免疫治疗敏感相关。CDK12双等位基因失活和缺失的前列腺癌患者基因组不稳定、局部串联重复增加、基因融合、新抗原负荷和T细胞浸润增加，能够从免疫检查点治疗中获益。TP53合并KRAS突变、TP53合并ATM突变则与高突变负荷、T细胞浸润增加相关。PBRM1、SMARCA4和ARID1A同属SWI/SNF染色质重塑复合物相关基因。SWI/SNF染色质重塑复合物通过调节基因组结构影响免疫治疗效果，相关基因的失活与免疫治疗敏感相关。SERPINB3/4是与自身免疫和过敏相关的卵清蛋白的同源基因，相关基因突变在肿瘤早期激发了免疫反应，进而能够被免疫检查点抑制剂重新激活。TET1是一个DNA去甲基化酶，是在21个与DNA甲基化密切相关的关键基因中突变频率最高的基因，且TET1突变在免疫检查点治疗反应组中显著富集。</p>
                
                <h4>  ·相关循证医学证据：</h4>
                <div class="bDetail">
                    <div>乳腺癌、头颈肿瘤、肺鳞癌等多种肿瘤与PDL1/2扩增</div>
                    <section>
                        <h4> 66.7% PDL1扩增实体瘤患者经免疫检查点治疗有效（2018《JAMA Oncology》）</h4>
                        <p>
                            118187例肿瘤样本中，PDL1扩增（该基因位于9p24.1，该区域同时具有PDL2和JAK2基因）患者共843例，发生率为0.7%，绝大多数（84.8%）PDL1扩增患者具有较低的TMB。PDL1扩增与免疫组化分析的PDL1表达并非完全相关。在一个单中心研究中，66.7%（9例患者中的6例）患者对免疫检查点治疗客观反应，所有治疗患者的中位PFS为15.2月，有效的患者包括脑胶质瘤1例（PFS≥5.2月），头颈肿瘤2例（PFS≥9和15.2月），转移性基底细胞癌2例（PFS为3.8和≥24.1月）和尿路上皮癌1例（PFS≥17.8月） (PMID：29902298) 
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>皮肤癌、子宫内膜癌、结直肠癌等多种肿瘤与POLE/POLD1突变</div>
                    <section>
                        <h4> POLE/POLD1突变免疫检查点治疗患者总生存期显著高于野生型患者（2019《JAMA Oncology》）</h4>
                        <p>
                            cBioPortal数据库47721例肿瘤样本中，纳入包含错义、移码、终止、无终止、剪切位点等所有POLE/POLD1变异， 2.79%和1.37%的患者发生POLE和POLD1突变。在绝大多数肿瘤中，突变患者TMB显著高于野生型患者。纳入一个1644例经ICI治疗的队列研究发现，POLE或者POLD1突变患者总生存期显著高于野生型人群（34月vs 18月，p=0.004） (PMID：31415061)
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div> 结直肠癌与POLE热点突变</div>
                    <section>
                        <h4> 四例POLE热点突变的高突变负荷结直肠癌患者对PD1抗体治疗反应为CR和PR（2019《JCO precision oncology》）</h4>
                        <p>
                            4例POLE热点突变（V411L和P286R）结直肠癌患者TMB为117-220/MB,其中2例患者为PDL1阴性，1例为PDL1弱阳性，经PD1抗体治疗后，两例患者为CR（缓解时间分别为28月和12月），两例患者为PR（缓解时间分别为14月和7月）。 (https://doi.org/10. 1200/PO.18.00214) 
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div> 脑胶质瘤与POLE热点突变</div>
                    <section>
                        <h4> 一例POLE胚系变异的脑胶质瘤患者对PD1抗体治疗影像学客观反应的案例报道（2016《Cancer Discovery》）</h4>
                        <p>
                            一例POLE胚系变异伴随高突变负荷多形性脑胶瘤患者经PD1治疗后发现颅内病灶影像学客观反应，进一步分析治疗后病灶发现大量的免疫细胞浸润。 (PMID：27683556) 
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>  子宫内膜癌与POLE热点突变</div>
                    <section>
                        <h4>  一例POLE突变的子宫内膜癌患者对PD1治疗对PD1抗体治疗超预期反应（维持14个月）的案例报道（2016《JCI》）</h4>
                        <p>
                            一例POLE突变（V41L（外切酶区域）和R114*）的子宫内膜癌患者对PD1抗体治疗具有超预期（维持14个月）反应，该患者同时具有高突变复核。（PMID: 27159395）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>  脑瘤、结肠癌等多种肿瘤与POLE/POLD1热点突变</div>
                    <section>
                        <h4>   特定POLE/POLD1热点突变与高突变负荷相关，是肿瘤的驱动因子（2017《CELL》）</h4>
                        <p>
                            该研究通过对将近10万例肿瘤样本测序数据进行分析发现，POLE、POLD1特定热点突变与高突变负荷相关，肿瘤的突变负荷情况可以作为POLE、POLD1基因驱动突变和乘客突变的区分指标。（PMID: 27159395）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>   前列腺癌与CDK12基因纯合失活</div>
                    <section>
                        <h4> CDK12双等位基因失活和缺失的前列腺癌患者基因组不稳定、局部串联重复增加、基因融合、新抗原负荷和T细胞浸润增加，能够从免疫检查点治疗中获益（2018《CELL》）</h4>
                        <p>
                            CDK12双等位基因失活和缺失的前列腺癌患者基因组不稳定、局部串联重复增加、基因融合、新抗原负荷和T细胞浸润增加，能够从免疫检查点治疗中获益。在11例CDK12突变患者中，4例患者进行了PD1抗体单药治疗，其中2例患者具有超乎寻常的的PSA反应（MSS患者一般对PD1抗体治疗不敏感）（PMID: 29906450）
                        </p>
                    </section>
                </div>

                <div class="bDetail">
                    <div>    非小细胞肺癌与TP53合并KRAS突变</div>
                    <section>
                        <h4>  多项研究发现TP53合并KRAS突变非小细胞肺癌患者能够从免疫检查点治疗中获益（2018《CELL》）</h4>
                        <p>
                            多线研究发现， KRAS合并TP53突变的非小细胞肺癌患者中，PD-L1 的表达显著提高，T 细胞的浸润性和肿瘤免疫敏感性增强，能够从PD1治疗中获益（[PMID:28039262; PMID:29572005; PMID:29484144）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>   非小细胞肺癌与TP53合并ATM突变</div>
                    <section>
                        <h4> TP53合并ATM突变与更高的TMB和经ICIs治疗后更好的OS和PFS相关（2019《JAMA Network Open》）</h4>
                        <p>
                            5个队列共计5781例NSCLC患者中发现TP53合并ATM突变与更高的TMB和经ICIs治疗后更好的OS和PFS相关,其中具有ICIs治疗患者有两个队列，共计1203例，具体生存数据如下：①、MSKCC ICIs治疗队列：TP53/ATM共突、TP53单独突变、ATM单独突变患者和无突变患者总生存期OS分别为未达到、14月、40月和22月，p=0.001；②、POPLAR和OAK队列：TP53/ATM共突、TP53单独突变、ATM单独突变患者和无突变患者中位PFS分别为10.4月、1.6月、3.5月和2.8月，p=0.01;中位OS分别为22.1月、8.3月.15.8月和15.3月，p=0.002（[PMID: 31539077）
                        </p>
                    </section>
                </div>

                <div class="bDetail">
                    <div>   肾癌与PBRM1基因纯合失活</div>
                    <section>
                        <h4>PBRM1突变肾癌患者PD1抗体临床获益率更高（54.2% vs 24%）（2018《Science》）</h4>
                        <p>
                            在35例肾细胞癌中发现，SWI/SNF染色质重塑复合物相关基因PBRM1基因失活与PD1抗体单药治疗获益密切相关（p=0.012），同时进一步在一个65例的经PD1抗体单药或者PD1联合CTLA4治疗的肾细胞癌队列中得到验证（p=0.0071）。总体而言，PBRM1失活（双等位基因失活或者完全缺失）患者免疫检查点抑制剂治疗获益率为54.17%，而PBRM1野生型患者或疑虑为24%。（PMID: 29301960）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div> 肾癌与PBRM1基因失活变异</div>
                    <section>
                        <h4> PBRM1突变肾癌患者中PBRM1作为免疫检查点治疗反应标志物的临床验证及其局限性（2019《JAMA Oncology》；2018《Nature medicine》）</h4>
                        <p>
                            在一个证明既往接受过抗血管生成治疗后抗PD1治疗相比依维莫司显著改善总生存的三期临床实验的肾细胞癌队列中对其中382例（总队列共803例）患者进行基因分析发现，PBRM1突变与PD1治疗更高的临床获益（34.6% vs 19.7% p=0.04）、PFS增加（HR为0.67，P=0.03）和OS增加（HR=0.67，P=0.03）相关。然而值得注意的是，既往研究发现，PBRM1失活状态与抗血管生成疗效相关且未经抗血管生成治疗的肾细胞癌患者PBRM1失活状态与免疫检查点疗效无关（PMID: 31486842；PMID：29867230）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>  非小细胞肺癌、类恶性横纹肌样瘤胸部肿瘤、高钙血型小细胞卵巢癌与SMARCA4纯合失活</div>
                    <section>
                        <h4> SMARCA4失活驱动的多种肿瘤PD1治疗有效的案例报道（2018《JNCI》；2019《Thoracic cancer》；2019《Annal of oncology》）</h4>
                        <p>
                            由SMARCA4失活的单基因疾病（低TMB）高钙血型小细胞卵巢癌，4例患者PD1抗体治疗有效（1例持续部分反应6个月；3例维持无疾病状态1.5年或者更长）。在11例样本中，绝大多数（8例）PDL1表达且具有强烈的T细胞浸润。1例SMARCA4完全失活（免疫组化阴性）、TMB相对较高（全外显子测序共找到396个突变，大约11个/Mb）的非小细胞肺癌部分反应，持续疾病控制时间超过14月。1例SMARCA4失活、PDL1阴性的胸部肿瘤经PD1抗体治疗11个月后，获得相对于基线高达-72%的PR（PMID:29365144；PMID:30972962; PMID:31114851）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div> 非小细胞肺癌与ARID1A基因失活变异</div>
                    <section>
                        <h4> ARID1A基因失活与NSCLC PDL1联合CTLA4治疗中位OS延长相关（2019 WCLC abstract；2018《Nature medicine》）</h4>
                        <p>
                            在一项三期临床试验MYSTIC研究（抗PDL1治疗durvalumab vs 抗PDL1联合CTLA4tremelimumab vs 铂类为基础的化疗）中，三组患者分别为374例、372例和372例，ARID1A突变患者在PDL1联合CTLA4治疗组中与中位OS延长相关（23.2月 vs 9.8月），然而在PDL1单药组和化疗组并未观察到类似现象（PDL1单药组为8.6月 vs 13.7月，化疗组为10.6月 vs 12.4月）。既往临床前研究发现，ARID1A失活导致ARID1A无法结合到MMR蛋白MSH2，增加突变频率，并且在ARID1A失活的卵巢癌小鼠模型中发现，PDL1抑制导致肿瘤负荷降低，以及带来相比于野生型小鼠更长的生存。（2019 WCLC abtract OA04.07；PMID：29736026）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div> 黑色素瘤与SERPINB3/4基因突变</div>
                    <section>
                        <h4>SERPINB3/4基因突变与黑色素瘤CTLA4和PD1抗体治疗疗效密切相关（2016《Nature Genetics》；2017《CELL》）</h4>
                        <p>
                            在俩个独立的黑色素瘤队列（174例）中发现，SERPINB3/4基因突变与黑色素瘤CTLA4抗体治疗疗效密切相关，多因素分析显示这两个基因突变与总生存密切相关且独立于突变负荷（队列1，HR为0.34，p=0.047；队列2，HR=0.32，p=0.01）。值得注意的是，TCGA未经免疫治疗的黑色素瘤队列中，SERPINB3/4基因突变与预后无关。另在一项针对未经CTLA4治疗，同时行PD1治疗的33例黑色素瘤患者研究发现，虽然SERPINB3/B4突变与治疗反应未能达到统计学显著性，但是6例突变患者中有5例患者达到疾病控制（CR/PR或者疾病稳定）。（PMID：27668655；PMID：29033130）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div> 皮肤癌、肺癌等多种肿瘤与TET1基因突变</div>
                    <section>
                        <h4>TET1基因突变与皮肤癌、肺癌等多种肿瘤免疫检查点治疗疗效密切相关（2019《Journal for ImmunoTherapy of Cancer》）</h4>
                        <p>
                            在21个与DNA甲基化密切相关的关键基因中，TET1突变在免疫检查点治疗反应组中显著富集。在发现组中（519例），TET1突变患者和野生型患者在客观缓解率（ORR，60.9% vs 22.8%，p＜0.001）、持续临床获益（DCB，71.4% vs 31.6%，p＜0.001）和无疾病进展生存期（PFS，HR=0.46，p=0.008）等各方面具有显著差异。在验证组中（1395例），相比于TET1野生型，TET1突变型患者具有显著的总生存获益（HR=0.47，p=0.019），而且与TMB、MSI和TET1突变的预后影响均完全独立（PMID：31623662）
                        </p>
                    </section>
                </div>

                <h4 id="m2-5"> 免疫治疗耐药驱动突变检测结果</h4>
                <div  class="table-680-1" style="width: 100%;">
                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 30px;">
                            <th> · 免疫治疗耐药驱动相关EGFR基因发生激活突变合并CTNNB1基因发生激活突变</th>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;font-weight: bold;background: #000;color: #fff;">
                            <td>    PD1等免疫检查点抑制剂治疗可能具有耐药风险(C)</td>
                        </tr>
                    </table>

                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 25px;text-align: center;">
                            <td style="color: #fff;background: red;"> EGFR基因发生激活突变</td>
                            <td> ALK基因未发生融合</td>
                            <td> STK11基因未发生失活变异</td>
                        </tr>
                        <tr style="line-height: 25px;text-align: center;">
                            <td style="color: #fff;background: red;">CTNNB1基因发生激活突变</td>
                            <td> PTEN基因未发生纯合失活变异</td>
                            <td> IFNGR1/2基因未发生纯合失活变异</td>
                        </tr>
                        <tr style="line-height: 25px;text-align: center;">
                            <td>IRF1基因未发生纯合失活变异</td>
                            <td> B2M基因未发生纯合失活变异</td>
                            <td>JAK1/2基因未发生纯合失活变异 </td>
                        </tr>
                        <tr style="line-height: 25px;text-align: center;">
                            <td>APLNR基因未发生纯合失活变异</td>
                            <td> PIAS4基因未发生扩增</td>
                            <td>SOCS1基因未发生扩增 </td>
                        </tr>
                       
                    </table>

                    

                </div>


                <h4> 体细胞突变相关基因详细信息</h4>
                <div  class="table-680-1" style="width: 100%;">
                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 40px;">
                            <th>基因 </th>
                            <th>核苷酸变化</th>
                            <th>氨基酸变化</th>
                            <th>外显子</th>
                            <th>变异类型</th>
                            <th>突变丰度</th>
                            <th>覆盖度</th>
                            <th>Cosmic计数</th>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>EGFR</td>
                            <td>c.2573T＞G</td>
                            <td>p.L858R</td>
                            <td>Exon21</td>
                            <td>错义突变</td>
                            <td>11.76%</td>
                            <td>119x</td>
                            <td>10256</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>CTNNB1</td>
                            <td>c.110C＞G</td>
                            <td>p.S37C</td>
                            <td>Exon3</td>
                            <td>错义突变</td>
                            <td>3.41%</td>
                            <td>264x</td>
                            <td>200</td>
                        </tr>
                    </table>


                    

                </div>

                <h4> · 结果说明</h4>
                <p style="font-size: 14px;">免疫治疗耐药可以由多种因素引起，以上基因通过不同机制导致免疫治疗耐药。EGFR、ALK基因与TMB、PDL1表达较低有一定关系，CTNNB1基因则是通过影响枝状细胞招募进抗PD1治疗的耐药。B2M基因纯合失活突变，主要通过损害抗原提呈机制使免疫治疗耐药。JAK1、JAK2、IFNGR1、IFNGR2、IRF1、APLNR、PIAS3和SOCS等基因的纯合失活突变，则是通过损害效应T细胞杀伤肿瘤细胞的信号通路（γ干扰素通路）导致免疫治疗耐药。PTEN基因表达缺失或者纯合失活突变，则可能是通过影响T细胞浸润使免疫治疗耐药。</p>

                <h4> · 相关循证医学证据：</h4>
                <div class="bDetail">
                    <div> 非小细胞肺癌与EGFR、ALK变异</div>
                    <section>
                        <h4>NCCN等指南推荐免疫治疗用于EGFR、ALK阴性患者，现阶段证据不支持EGFR突变患者进行单药免疫治疗，多项早期临床试验显示EGFR TKIs联合免疫治疗效果不一，毒副作用大</h4>
                        <p>
                            目前的证据显示，EGFR突变患者对PD1/PDL1免疫检查点单药治疗反应不佳。一项针对比较nivolumab、pembrolizumab、atezolizumab和化疗药多西他赛二线治疗三项研究的Meta分析显示，EGFR突变患者使用免疫治疗不能带来OS的获益[18]。同样，Keynote001研究结果显示，pembrolizumab治疗PD-L1表达≥50%NSCLC中，EGFR野生型NSCLC患者的中位OS为15.7个月，ORR为40%，但在突变型患者中，中位OS仅为6.5个月，ORR仅为20%，EGFR突变型NSCLC使用免疫治疗的疗效明显劣于EGFR野生型患者，因此目前NCCN指南并不推荐EGFR突变NSCLC患者接受免疫治疗。目前有CheckMate012、NCT02013219、NCT0208812、KeyNote021、TATTON、CAURAL等多项早期临床试验报道了EGFR TKIs联合免疫治疗的结果，结果如下表罗列。由于临床试验规模均较小，无法得出明确结论，但是大致可以得到以下有待证实的推论：1、EGFR TKIs联合免疫治疗无法提高ORR，甚至可能会降低ORR，KeyNote021研究厄洛替尼联合帕博利珠单抗的有效率仅为41.7%，远低于其他临床试验厄洛替尼单药的70-80%，CAURAL研究也可以得到类似的结果；2、以NCT02013219研究和TATTON研究为例，未经EGFR TKIs治疗的患者，EGFR TKIs联合免疫治疗毒副作用发生比例大，其中吉非替尼和奥希替尼引起毒副作用的比例可能比厄洛替尼高；3、以KeyNote021厄洛替尼联合帕博利珠单抗为例，ORR降低但是PFS提高，CAURAL 也得到类似的结果，EGFR TKIs联合免疫治疗可能会延长患者PFS，延缓EGFR TKIs耐药的出现。（PMID：27765535；https://doi.org/10.1093/annonc/mdw594.005；Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4；PMID：30529597；
                        </p>
                        <p>
                            https://doi.org/10.1016/S1556-0864(16)30246-5；PMID: 30763730）
                        </p>
                    </section>
                </div>
                <div  class="table-680-y" style="width: 100%;">

                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 30px;">
                            <th>研究</th>
                            <th>干预手段</th>
                            <th>EGFR突变人群</th>
                            <th>疗效</th>
                            <th>毒副作用AEs</th>
                        </tr>
                        <tr>
                            <td>CheckMate012</td>
                            <td>厄洛替尼+纳武利尤单抗</td>
                            <td>21例（20例经E治疗，1例Naive）</td>
                            <td>ORR 19% <br>
                                24周PFS率51%
                            </td>
                            <td>
                                3级毒性发生率为19%，2例终止治疗，未发生4级-5级毒性
                            </td>
                        </tr>
                        <tr>
                            <td>NCT02013219</td>
                            <td>厄洛替尼+atezolizumab</td>
                            <td>20例naive</td>
                            <td>ORR 75% <br>
                                mPFS 11.3月
                            </td>
                            <td>
                                39%患者有3-4级AEs，主要为发热和ALT升高，未见肺炎和间质性肺病
                            </td>
                        </tr>
                        <tr>
                            <td>NCT0208812</td>
                            <td>吉非替尼+durvalumab</td>
                            <td>9例naïve（A组）<br>
                                10例经28d G治疗（B组）
                            </td>
                            <td>
                                ORR 77.8% (A) <br>
                                ORR 80% (B)
                            </td>
                            <td>
                                导致治疗终止的3-4级AEs发生在B组共4例
                            </td>

                        </tr>
                        <tr>
                            <td>KeyNote021</td>
                            <td>吉非替尼+帕博利珠单抗</td>
                            <td>12例naïve（A） <br>
                                7例naïve（B）
                            </td>
                            <td>
                                ORR 41.7% SD 41.7%<br>
                                mPFS 19.5月（A）<br>
                                ORR 14.3%<br>
                                57.1%未评估<br>
                                mPFS 1.4月（B）
                            </td>
                            <td>
                                33.3%（4例）发生3级以上AEs，<br>其中3例导致治疗终止
                        85.7%（6例）发生3级以上AEs，<br>其中5例导致治疗终止
                            </td>
                        </tr>
                        <tr>
                            <td>TATTON</td>
                            <td>奥希替尼+durvalumab</td>
                            <td>23例经EGFRTKIs治疗(A)
                                11例Naïve（B）
                            </td>
                            <td>ORR 57.1% T790M阳性67%，阴性21%
                                ORR 80%（B）
                            </td>
                            <td>
                                A组：26%发生间质性肺病 <br>
                                B组：64%发生间质性肺病
                            </td>

                        </tr>
                        <tr>
                            <td>CAURAL</td>
                            <td>奥希替尼+durvalumab（对照组为奥希替尼单药）</td>
                            <td>12例经治且T790M阳性</td>
                            <td>ORR 64%（低于对照组的80%） <br>
                                PFS未达到（对照组为19.3月） <br>
                                12月生存率为86%（对照组为100%）
                            </td>
                            <td>
                                8%发生3级以上AEs，间质性肺病发生1例且推测由奥希替尼引起
                            </td>
                        </tr>
                    </table>
                </div>

                <div class="bDetail">
                    <div> 非小细胞肺癌与STK11基因失活</div>
                    <section>
                        <h4>STK11是独立于TMB和PDL1表达的非小细胞肺癌PD1抗体治疗耐药预测因子（2018《Cancer Discovery》）</h4>
                        <p>
                            在队列1（SU2C）中，KRAS合并STK11突变（KL）组、KRAS合并TP53（KP）组和KRAS单独突变（K-only）组PD1治疗客观缓解率分别为7.4% vs 35.7% vs 28.6%，p＜0.001。在队列2（Checkmate-057）中，三组则分别为0% vs 57.1% vs 18.2%，p=0.047。在肺腺癌中，STK11变异是在TMB较高或者高的亚组中，与PDL1阴性显著相关的标志物，进一步研究发现，STK11变异（突变或者表达缺失）对PD1治疗的影响在PDL1阳性的NSCLC一样可以观察到，在一组66例PDL1阳性患者的验证队列中，STK11突变（不管KRAS基因状态）与STK11完整的患者相比有效率显著降低（ORR，0% vs 34.5%， p=0.026）。STK11基因变异的耐药机制可能与趋化因子/细胞因子环境改变、效应T细胞代谢限制和抗原性损害等有关（PMID：29773717）
                        </p>
                    </section>
                </div>

                <div class="bDetail">
                    <div>  肝癌与CTNNB1基因激活</div>
                    <section>
                        <h4> β-catenin活化提升免疫逃逸，导致肝细胞癌中抗PD1治疗耐药（2019《Cancer Discovery》）</h4>
                        <p>
                            动物模型证明，β-catenin (CTNNB1)通过影响枝状细胞招募进而导致肝细胞癌动物模型对抗PD1治疗耐药，进一步的临床观察发现，15例肝细胞癌患者进行抗PD1治疗，6名（40%）对治疗产生响应，3例CTNNB1突变的患者中，1例响应，2例无响应。（PMID：31186238）
                        </p>
                    </section>
                </div>

                <div class="bDetail">
                    <div>  黑色素瘤与JAK1、JAK2和B2M的纯合失活</div>
                    <section>
                        <h4>  JAK1、JAK2和B2M的纯合失活突变与PD1抗体治疗继发耐药有关（2016《NEJM》）</h4>
                        <p>
                            针对4名PD1抗体治疗原始有效，后续发生继发性耐药患者原发灶和复发病灶进行测序。患者1发生了一个JAK1 Q503*的纯合
                            终止突变（55个复发病灶新发突变中出现的3个纯合突变）；患者2发生了一个纯合JAK2 F547的剪切突变（76个复发病灶新发突变中出现的唯一一个纯合突变），后续的RNA测序确认为功能失活突变。随后的细胞功能实验确认，JAK1/2失活突变通过γ干扰素通路导致免疫治疗耐药。患者3中发现了B2M 1号外显子的一个纯合移框突变（24个复发病灶新发突变中出现的唯一一个纯合突变），免疫组化发现相对于基线肿瘤，复发病灶中，MHC 1类重链缺乏膜外定位。患者4没有找到明确定义的基因变异。（PMID：27433843）
                        </p>
                    </section>
                </div>

                <div class="bDetail">
                    <div>  黑色素瘤、结直肠癌与JAK1和JAK2的纯合失活突变</div>
                    <section>
                        <h4> JAK1、JAK2的纯合失活突变与PD1抗体治疗原发耐药相关（2017《Cancer Discovery》）</h4>
                        <p>
                            23名黑色素瘤患者中的1位，16位错配修复缺陷肠癌中的1位，分别出现JAK1（P429S，位于SH2结构域，VAF为0.71，很可能是纯合突变）和JAK2（W690*终止突变，VAF为0.94，伴随该基因区域正常基因的杂合缺失，为明确纯合突变）失活突变，虽然均具有高突变负荷，但是对PD1抗体治疗原发耐药。后续的细胞学实验证明，JAK1/2失活导致γ干扰素通路介导的PDL1表达增加的能力受到损害。（PMID：27903500）
                        </p>
                    </section>
                </div>
                 <div class="bDetail">
                    <div>  非小细胞肺癌与JAK2和B2M的纯合失活突变</div>
                    <section>
                        <h4>  单中心PD1治疗经验确认JAK2突变与耐药相关，但是B2M突变与预期结果不符合（2018《JCO》）</h4>
                        <p>
                            240例具有完整临床数据的PD1抗体治疗患者，经过二代测序分析，发现1例JAK2纯合突变导致原发耐药，但是1例B2M失活突变、高TMB的患者，PD1抗体治疗疗效评估为PR。（PMID：29337640）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>  平滑肌肉瘤与PTEN的纯合失活突变</div>
                    <section>
                        <h4>   双等位基因PTEN缺失通过上调VEGFA和STAT3表达量导致PD1治疗耐药（2017《Immunity》）</h4>
                        <p>
                            在一例未经治疗的转移性平滑肌肉瘤患者，经PD1抗体单药治疗，经历两年的肿瘤完全缓解。针对原发灶和单发治疗抵抗转移灶的基因组多组学整合分析（外显子组和转录组），在16个继发突变中，PTEN双等位基因缺失（点突变合并杂合缺失）是唯一一个与致癌信号通路相关的突变，进一步的转录组表达量分析验证了之前的研究，PTEN缺失通过上调VEGFA和STAT3表达量导致PD1治疗耐药。进一步在TCGA数据库中241例未经治疗的肉瘤中分析发现，PTEN相关区域缺失和PTEN致癌突变共同出现的患者，STAT3表达量显著上调，而单独出现PTEN相关区域缺失或PTEN致癌突变的患者，则未能观察到相关现象。（PMID：29337640）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>   黑色素瘤与PTEN的表达缺失</div>
                    <section>
                        <h4>   PTEN表达缺失通过增加免疫抑制细胞因子表达量，降低肿瘤中T细胞浸润导致T细胞介导的免疫治疗耐药（2016《Cancer Discovery》）</h4>
                        <p>
                            对一组39名转移性黑色素瘤患者进行PD1抗体治疗，PTEN相比正常PTEN缺失（免疫组化，10%以下的肿瘤细胞表达定义为缺失）的患者，肿瘤缩小比例显著增加（P=0.029）。后续的细胞学实验和动物学实验证明，PTEN表达缺失通过增加免疫抑制细胞因子表达量，降低肿瘤中T细胞浸润导致T细胞介导的免疫治疗耐药（PMID：26645196）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>    黑色素瘤、肺癌、膀胱癌等多种肿瘤与IFNγ通路基因缺陷</div>
                    <section>
                        <h4>   IFNγ通路基因缺陷与（2016《Cancer Discovery》）</h4>
                        <p>
                            IFNγ是宿主免疫反应的关键细胞因子，其通路基因状态与免疫检查点治疗疗效密切相关。在一个CTLA4治疗的黑色素瘤队列中发现，IFNγ通路基因缺陷（IFNGR1、IFNGR2、JAK2、IRF1基因缺失和IFNγ通路抑制基因SOCS1、PIAS4基因扩增）在耐药组中显著富集，且IFNγ通路基因缺陷组患者总生存时间显著长于野生型患者（p=0.0018）。另一项CRISPR筛查研究则发现IFNγ通路相关基因APLNR失活与免疫治疗耐药相关。一项包含黑色素瘤、肺癌、膀胱癌、头颈肿瘤等多种肿瘤共计249例经免疫检查点治疗的患者一样发现IFNγ通路基因缺陷中耐药组患者中显著富集（19/123 vs 3/70 p=0.019）（PMID：26645196）
                        </p>
                    </section>
                </div>


                <h4 id="m2-6">免疫治疗超进展相关基因检测结果</h4>

                <div  class="table-680-1" style="width: 100%;">
                    <table style="width: 100%;margin-bottom: 40px;" border="1">
                        <tr style="line-height: 30px;">
                            <th> · 免疫治疗超进展相关基因无变异</th>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;font-weight: bold;">
                            <td>   PD1等免疫检查点抑制剂可能无超进展风险</td>
                        </tr>
                    </table>
                    <table style="width: 100%;margin-bottom: 20px;" border="1">
                        <tr style="line-height: 30px;text-align: center;">
                            <td> CDKN2A/B基因未发生缺失</td>
                            <td>MDM2基因未发生扩增</td>
                            <td>MDM4基因未发生扩增</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td> DNMT3A基因未发生突变</td>
                            <td>EGFR基因未发生扩增</td>
                            <td>11q13(CCND1、FGF3、FGF4、FGF19)基因未发生扩增</td>
                        </tr>
                        
                    </table>

                </div>

                <h4>· 结果说明</h4>
                <p style="font-size: 14px;">免疫治疗耐药可以由多种因素引起，以上基因通过不同机制导致免疫治疗耐药。EGFR、ALK基因与TMB、PDL1表达较低有一定关系，CTNNB1基因则是通过影响枝状细胞招募进抗PD1治疗的耐药。B2M基因纯合失活突变，主要通过损害抗原提呈机制使免疫治疗耐药。JAK1、JAK2、IFNGR1、IFNGR2、IRF1、APLNR、PIAS3和SOCS等基因的纯合失活突变，则是通过损害效应T细胞杀伤肿瘤细胞的信号通路（γ干扰素通路）导致免疫治疗耐药。PTEN基因表达缺失或者纯合失活突变，则可能是通过影响T细胞浸润使免疫治疗耐药。</p>
                
                <h4>· 相关循证医学证据：</h4>
                <div class="bDetail">
                    <div>    膀胱癌、乳腺癌、子宫内膜间质肉瘤等多种肿瘤与MDM2/4、EGFR等</div>
                    <section>
                        <h4>   MDM2/MDM4明确与免疫治疗超进展相关，EGFR变异有较高可能性与超进展相关，DNMT3A有可能与超进展相关（2017《Clin Cancer Res》）</h4>
                        <p>
                            文献中超进展定义：1、用药后出现明显进展，治疗失败时间（TTF）＜2个月；2、与治疗前影像学相比肿瘤负荷增大50%；3、＞2倍的肿瘤进展速度。6位MDM2/MDM4患者中，所有人的TTF时间均小于2个月，其中4名患者为严格定义的超进展患者，出现肿瘤明显增大（55%-258%）和显著的进展加速（2.3倍、7.1倍、7.2倍和42.3倍）。10名EGFR变异的患者中，8名患者（单独EGFR扩增 2名、合并EGFR扩增、突变4名、单独EGFR突变2名）TTF（治疗至失败时间）小于两个月，其中两名患者（单独EGFR突变1名，EGFR扩增、突变合并1名）出现严格定义的超进展（36倍和42倍于2个月治疗前肿瘤负荷进展速度，分别增大53.6%和125%）。4名DNMT3A变异（突变或扩增）患者中，3名患者TTF小于2个月。（PMID：28351930）
                        </p>
                    </section>
                </div>
                <div class="bDetail">
                    <div>    肺癌、食管癌和肾癌与MDM2/4、EGFR和11q13基因扩增</div>
                    <section>
                        <h4> 4名超进展患者出现中MDM2/4扩增、EGFR扩增和11q13扩增事件（2017 ESMO abstrat）</h4>
                        <p>
                            文献中超进展定义：1、接受PD-1抗体治疗后第一次复查CT，就出现了疾病进展；2、肿瘤大小增大了50%；3、肿瘤生长速度增快了2倍以上的患者。66%（2/3）的MDM2/MDM4扩增患者，50%（1/2）的EGFR扩增患者和43%（3/7）的11q13扩增（CCND1、FGF33/4/9同时存在）出现超进展。（ESMO abstract：Singavi A K,et al. [J]. Annals of Oncology, 2017, 28(suppl_5).）
                        </p>
                    </section>
                </div>

                <div class="bDetail">
                    <div>   非小细胞肺癌与MDM2/4基因扩增</div>
                    <section>
                        <h4>  MDM2/4基因扩增不一定与超进展相关（2018《JCO》）</h4>
                        <p>
                            240名具备完整资料的免疫检查点抑制剂治疗患者中，8名患者出现DMD2/DMD4扩增，但是中位无疾病进展生存期与总体数据与其他患者并没有明显差异。（PMID：29337640）
                        </p>
                    </section>
                </div>

                <div class="bDetail">
                    <div>  非小细胞肺癌与MDM2基因扩增、CDKN2A/B缺失</div>
                    <section>
                        <h4>  5例NSCLC超进展患者中1例为MDM2扩增，4例为CDKN2A/B缺失，非超进展患者无相关基因变异（2019 ASCO abstrat）</h4>
                        <p>
                            在20例患者中，其中5例患者出现了超进展，研究者采用NGS、IHC、FISH检测这些患者的基因。5例出现超进展的患者NGS 分析显示, 1 例HPD患者 MDM2 扩增, 4 例患者CDKN2A/B缺失。另外，非超进展患者中IHC分析没有检测到MDM2基因或蛋白的扩增，NGS 分析也没有发现 MDM2 和/或CDKN2A基因改变。5例NSCLC超进展患者中，1例MDM2扩增，4例患者CDKN2A/B缺失，其他非超进展患者无相关变异（J Clin Oncol 37, 2019 (suppl; abstr e2)
                        </p>
                    </section>
                </div>

                <div class="bDetail">
                    <div>  非小细胞肺癌与MDM2/4基因扩增</div>
                    <section>
                        <h4>MDM2/4基因扩增与超进展无关（2019《Clin Cancer Res》）</h4>
                        <p>
                            187例经ICI治疗的NSCLC患者中发现39例（25.7%）超进展患者。超进展组11例患者，非超进展组17例患者共获得30例FFPE组织，通过FISH检测MDM2/4发现，超进展组发现3例患者扩增（2 MDM2、1 MDM4），非超进展组发现6例扩增（4例MDM2、1例MMD4和1例MDM2合并MDM4），MDM2/4扩增与超进展无关。（PMID：30206165）
                        </p>
                    </section>
                </div>


                <h4 id="m2-7">HLA分型检测结果</h4>

                <div  class="table-680-1" style="width: 100%;">
                    <table style="width: 100%;margin-bottom: 40px;" border="1">
                        <tr style="line-height: 30px;">
                            <th> ·  A、B、C三个等位基因均为杂合状态</th>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;font-weight: bold;">
                            <td>  PD1等免疫检查点抑制剂可能效果不显著</td>
                        </tr>
                    </table>
                    <table style="width: 100%;margin-bottom: 20px;" border="1">
                        <tr style="line-height: 30px;text-align: center;">
                            <td> HLA-A11:01 HLA-A24:02</td>
                            <td>HLA-B35:05 HLA-B55:02</td>
                            <td>HLA-C04:01 HLA-C12:03</td>
                        </tr>
                        
                    </table>

                </div>


                <h4>· 结果说明</h4>
                <p style="font-size: 14px;">HLA分型与免疫治疗疗效高度相关。HLA(human lymphocyte antigen ，人类淋巴细胞抗原)，是编码人类的主要组织相容性复合体（MHC）的基因。HLA是免疫系统区分自身和异体物质的基础。HLA主要包括HLA Ⅰ类分子和Ⅱ分子。HLAⅠ类分子又进一步细化分成A、B、C三个基因。特定的超型，如HLA-B44，与免疫检查点抑制剂治疗疗效好相关；HLA-B66（包括HLA-B*15：01），与免疫检查点抑制剂治疗疗效差相关。HLA Ⅰ类三个基因均纯合，免疫检查点抑制剂治疗反应更好。HLA杂合缺失的基因相关的新抗原可能在个性化治疗疫苗或者特异性细胞治疗中无效。</p>

                <h4>· 相关循证医学证据：</h4>
                <div class="bDetail">
                    
                    <section>
                        <h4>1535例晚期癌症患者接受免疫检查点抑制剂治疗的HLA Ⅰ类分子分型整合分析（2018《science》）</h4>
                        <p>
                            （A）HLAⅠ类分子三个基因位置至少一个杂合的患者，总生存较短，风险比较高（队列1：杂合282名，至少一个纯合87名，HR=1.4（1.02-1.9），P=0.036；队列2：杂合899名，至少一个纯合267名，HR=1.31（1.03-1.7），P=0.028）；
                        </p>
                        <p>
                            （B）黑色素瘤患者中，B44超型的患者，总生存较长，风险比较低（队列1：HLA-B44（+）55名；HLA-B44（-）109名，HR=0.5（0.32-0.76），P=0.001；队列2：HLA-B44（+）44名；HLA-B44（-）106名，HR=0.32（0.09-1.1），P=0.05）；
                        </p>
                        <p>（C）黑色素瘤患者中，B62超型（包括HLA-B*15：01）的患者，总生存较短，风险比较高。整合分析中，两个队列324名黑色素瘤患者中，B62超型患者风险比较高（HR=2.29 (1.40–3.74) P=0.0007）；类似于B62超型的B*15:01风险比较高（HLA-B*15:01（+）142名，HLA-B*15:01（-）22名，HR=2.21 (1.33–3.70)，P=0.002）（Chowell D,et al. [J]. Science, 2018, 359(6375): 582-587.）</p>
                    
                    </section>
                </div>

                <h4 id="m2-8">肿瘤新抗原检测结果</h4>
                <div  class="table-680-1" style="width: 100%;">
                    
                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 30px;text-align: center;">
                            <td> 基因</td>
                            <td>多肽</td>
                            <td>亲和力（突变/正常）</td>
                            <td>突变点（克隆组成）</td>
                            <td>HLA分子</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td> 无</td>
                            <td>无</td>
                            <td>无</td>
                            <td>无）</td>
                            <td>无</td>
                        </tr>
                        
                    </table>

                    <p style="font-size: 12px;color: #999999;"></p>
                </div>

                <h4>·结果说明</h4>
                <p style="font-size: 14px;">
                    新抗原是指因肿瘤基因突变所导致的能够被该患者免疫系统HLA分子所识别，有潜力能够激活患者免疫系统的新生抗原，这是一组异常多肽片段。新抗原预测信息能够作为癌症个性化治疗疫苗或者特异性细胞治疗最核心的信息。新抗原预测一般 通过外显子组测序得到该患者所有的编码区域基因突变，进一步通过外显子组或者转录组获得该患者的HLA分型，根据基因突变信息和HLA分子信息，预测各个突变位点与该患者HLA分子结合的亲和力，并进一步通过转录组测序筛选其中表达的新抗原。本次未行转录组检测，会明显降低新抗原预测的准确性。
                </p>

                <h4 id="m2-9">免疫治疗解读说明</h4>
                <h4>·免疫治疗与肿瘤免疫</h4>
                <p style="font-size: 14px;">自2012年，约翰霍普金斯大学PD1抗体临床试验结果发表在《新英格兰医学杂志》之后，免疫治疗真正进入临床医生和产业界的视野，并迅速取代靶向治疗成为肿瘤治疗最新最主流的治疗研究方向。CTLA4、PD1抗体以惊人的产业化速度和疗效，迅速在多个癌种中获批，并在肺癌中成为一线治疗药物。PDL1表达、微卫星不稳定迅速成为有效协助患者药物筛选的分子标志物，肿瘤突变负荷TMB、新抗原负荷、肿瘤CD8+T淋巴细胞浸润状态等在各种数据中证明具有筛选有效患者的能力，然而，新型免疫治疗手段以超越基础研究的速度在发展，免疫治疗人群筛选和联合治疗时机选择远远没有到达完美，新的标志物层出不求
                    肿瘤免疫治疗是通过协助免疫系统发挥被抑制或者缺失的免疫能力，进而实现肿瘤治疗的手段。更好的理解肿瘤免疫过程，能够协助我们对各种新型肿瘤免疫治疗手段和新型标志物形成更好的全局性理解，以便我们更好的采取与化疗、放疗、靶向治疗的联合治疗手段，优化免疫治疗时机和方式的选择。肿瘤免疫周期理论是由Mellman等人提出来的肿瘤免疫过程框架，目前已经成为肿瘤免疫学研究和临床应用的思维框架。
                </p>
                <h4>肿瘤免疫周期理论</h4>
                <p style="font-size: 14px;">
                    肿瘤免疫治疗是通过协助免疫系统发挥被抑制或者缺失的免疫能力，进而实现肿瘤治疗的手段。更好的理解肿瘤免疫过程，能够协助我们对各种新型肿瘤免疫治疗手段和新型标志物形成更好的全局性理解，以便我们更好的采取与化疗、放疗、靶向治疗的联合治疗手段，优化免疫治疗时机和方式的选择。肿瘤免疫周期理论是由Mellman等人提出来的肿瘤免疫过程框架，目前已经成为肿瘤免疫学研究和临床应用的思维框架。
                </p>
                <div class="imgBox">
                    <img src="./img/680/img5.png" alt="">
                </div>
                <p style="font-size: 14px;">
                    ·1）肿瘤细胞死亡并释放肿瘤特异抗原
                    从某种意义上说，肿瘤是由基因突变积累形成的疾病，同时，肿瘤基因突变也是肿瘤免疫过程发生的主要驱动因素。各种原因形成的肿瘤基因突变，部分情况下会让肿瘤细胞表达出与未突变基因不一样的蛋白质，其中部分突变蛋白的肽段会被身体的免疫系统识别为“外源”抗原，即所谓的“新抗原”。当肿瘤因为各种原因死亡后，含有新抗原的蛋白就会从肿瘤细胞中释放出来，进而驱动肿瘤免疫反应。所以，部分情况下，放疗、化疗、靶向治疗等治疗手段会跟免疫检查点抑制剂治疗形成协同增强作用，也是因为该原因引起。最新部分研究甚至发现，不管PDL1表达状态，PD通路抗体联合化疗的疗效远高于单独化疗。微卫星高不稳定、肿瘤突变负荷高的肿瘤患者，一般情况下免疫检查点抑制剂具有更好的疗效，也均是因为一般情况下，更高的突变负荷，意味着更多的新抗原可能性。
                </p>
                <p style="font-size: 14px;">
                    ·2）抗原提呈细胞摄取并处理肿瘤新抗原
                    抗原提呈细胞摄取含有新抗原的突变蛋白，并将水解为可以结合到MHC（主要组织相容性复合物，又称为HLA人类白细胞抗原）的肽段。抗原提呈细胞需要有包括促炎症细胞因子和肿瘤细胞死亡释放的信号因子在内的多种免疫原性信号才能够有效启动，因此，不同免疫状态下的肿瘤，新抗原的提呈效率是不一样的。不同人的MHC具有异质性，所以，不同患者哪些新抗原能够被提呈是不一样的。目前通过生物信息手段，新抗原能够以一定的准确性被预测出来。目前有研究通过预测的新抗原进行个性化治疗疫苗设计，促进抗原提呈过程，并取得了相当惊人的效果。
                </p>
                <p style="font-size: 14px;">

                    ·3）抗原提呈细胞进入淋巴结激活T细胞
                    （抗原提呈细胞被新抗原激活后，进入淋巴结激活初始T细胞。初始T细胞在共刺激分子的协同作用下诱导T细胞增殖并分化成为激活免疫杀伤的效应T细胞和抑制免疫杀伤的调节性T细胞，并通过两者比例的精确控制达成免疫反应性质确定和平衡。重组白细胞介素2（IL-2）即通过该环节调节肿瘤免疫反应。
                </p>

                <p style="font-size: 14px;">
                    ·4）激活的T细胞离开淋巴结进入循环系统
                    激活的T细胞基于细胞黏附分子组分变化的原因，脱离淋巴结进入循环系统。
                </p>

                <p style="font-size: 14px;">
                    ·5）T细胞穿过血管壁浸润到肿瘤微环境
                    肿瘤细胞死亡等原因引起的局部免疫反应会让周围组织跟炎症反应一样释放细胞因子和趋化因子，结合该部位血管内皮细胞由于炎症反应表达量增加的附着蛋白，让循环系统中的T细胞通过与血管内皮细胞锚定后进入肿瘤微环境中。初步研究结果表明，抗血管生成治疗与免疫治疗能够起到非常好的协同作用，部分临床试验中甚至提高将近一倍的治疗效果。
                </p>

                <p style="font-size: 14px;">
                    ·6）T细胞通过特异性受体识别肿瘤细胞
                    肿瘤细胞和一般体细胞一样，在核糖体进行蛋白质翻译的过程中，会有一定比例的缺陷蛋白并会被水解成肽段，其中能够被MHC结合的潜在抗原会被提呈到细胞膜表面。T细胞通过特异性受体（TCR）识别肿瘤细胞表面的新抗原。有研究表明，部分肿瘤中，肿瘤细胞MHC缺失对于免疫逃逸的发生贡献重要意义。目前CAR-T和TCR-T是重点研究方向，并在部分肿瘤中发挥惊人的治疗效果。CAR-T治疗又称人工合成嵌合抗原受体T细胞治疗，直接取代T细胞识别肿瘤细胞的方式，而TCR-T则是通过筛选分离针对肿瘤特定抗原的TCR，将原来未能识别肿瘤细胞的T细胞改造成能够识别肿瘤细胞的T细胞。
                </p>

                <p style="font-size: 14px;">
                    ·7）肿瘤细胞被T细胞识别并溶解消灭
                    当效应T细胞识别出肿瘤细胞表面的特异性抗原后，胞浆内储存的效应分子将朝目标方向释放，在不影响周围正常细胞的情况下溶解肿瘤细胞。CD8+T细胞是最重要的执行细胞杀伤的效应T细胞，所以，一般情况下，其肿瘤微环境浸润情况与免疫治疗疗效正相关。同时，PD1和CTLA-4是T细胞表面的抑制性受体，肿瘤细胞通过相应配体的表达，抑制T细胞的免疫杀伤作用。
                </p>

                <h4>·肿瘤免疫表型理论</h4>
                <div class="imgBox">
                    <img src="./img/680/img6.png" alt="">
                </div>
                <div class="display-aw">
                    <section style="font-size: 14px;width: 50%;padding-top: 140px;">
                        <p>肿瘤免疫表型理论是由Mellman在肿瘤免疫周期的基础上，进一步根据最新的研究成果，细化发展出来的一套肿瘤免疫分型体系。该分型体系根据相应的生物学机制，将肿瘤分成免疫沙漠型（棕色）、免疫豁免型（蓝色）和炎症型（红色）三种，并进一步根据宿主基因、微生物组、环境因素、治疗药物和癌症共五个维度，将影响免疫原性的多种研究进展整合成如下图所示，与免疫治疗疗效和免疫原性相关的癌症-免疫设定点。</p>
                        <p>癌症免疫设定点是指产生有效癌症免疫原性所需克服的阈值，为指导免疫治疗临床应用和研究提供一个系统性框架。该设定点可以理解为理解为刺激因子、抑制因子和TCR结合信号（T细胞抗原受体与新抗原、癌症相关抗原等癌症抗原的亲和力）的平衡。癌症免疫治疗主要是针对肿瘤部位，通过增加的刺激因子、减少抑制因子或者增加TCR结合信号这三种方式进行的。</p>
                    </section>
                    <section>
                        <img src="./img/680/img7.png" alt="">
                    </section>
                </div>
                <h4>·免疫检查点抑制剂疗联合传统治疗研究进展</h4>
                <p style="font-size: 14px;">
                    免疫检查点抑制剂单药治疗虽然在临床治疗中显示出广泛的抗癌效果，不同癌种的总体有效率基本在20%左右，即使通过多种标志物进行预测可一定程度上减少无效人群，但其获益人群一样有限。从肿瘤免疫过程上看，将免疫阻隔型和免疫沙漠型的“冷”肿瘤，转变成免疫炎症型的“热”肿瘤，扩大免疫检查点抑制剂的获益人群，可以通过联合治疗的方式进行。对PDL1、MSI、TMB等各类型标志物预测检查位点抗体单药治疗效获益可能性较低的患者，最好进行检查位点抗体与其他治疗方式的联合治疗。多项研究发现放疗、化疗和靶向治疗等传统治疗联合免疫检查点抑制剂治疗能够获得惊人的效果，中位生存期、无疾病进展生存期和有效率等疗效指标翻倍的情况。同时，值得注意的是，联合治疗会成倍甚至多倍的提高毒副反应。基于对肿瘤免疫过程理解的加深，特异性针对特定肿瘤免疫过程的免疫治疗是联合治疗的更优选择。
                </p>

                <h4>·新型免疫治疗手段研究进展</h4>
                <p style="font-size: 14px;">
                    免疫治疗是癌症治疗有史以来最激动人心的治疗领域，甚至有的医生认为，癌症免疫治疗让人类真正真正看到了癌症被治愈的希望。随着PD1抗体在各癌种中的攻城略地，新型的免疫治疗手段也展现出未来的王者之相。
                </p>
                <p style="font-size: 14px;">
                    ·1）个性化癌症治疗疫苗 <br>
                    癌症疫苗，这种通过主动免疫去扩大肿瘤特异性T细胞反应的治疗方式，一直被认为是癌症免疫治疗的有效手段。尽管大家能够清晰看到癌症疫苗的合理性，但是，过去在临床方面的尝试都是不成功的。不同患者之间的肿瘤抗原具有强烈的多样性，因此，个性化癌症疫苗的发展是必要的。随着二代测序和生物信息工具的逐步完善，癌症疫苗的核心环节，新抗原预测逐渐成熟，该技术在最近的研究中取得突破性的进展，且由于安全性较好，是最值得跟进参与的新型癌症免疫治疗手段之一。
                </p>
                <div class="imgBox">
                    <img src="./img/680/img8.png" alt="">
                </div>
                <p style="font-size: 14px;">
                    ·2）免疫检查点抑制剂相关抗体
                    肿瘤免疫检查点不仅仅PD1和CTLA-4，还有至少几十种免疫检查点。目前该领域，IDO抑制剂、LAG3抑制剂在早期临床试验中显示出相当好的疗效，与PD1联合用药的情况下，部分结果甚至成倍提升有效率，其中IDO抑制剂，已经进入三期临床临床试验（注：IDO抑制剂Epacadostat与Keytruda联用的关键三期临床试验ECHO-301失败）。
                </p>
                <p style="font-size: 14px;">
                    ·3）CAR-T和TCR-T治疗
                    CAR-T和TCR-T都属于细胞治疗的范畴，主要通过对患者自身的T细胞进行工程化改造，让其能够发挥肿瘤细胞的杀灭功能。CAR-T，又称嵌合抗原受体T细胞治疗，是通过人工合成的受体使患者自身的T细胞能够进行肿瘤细胞识别，进而发挥肿瘤细胞杀伤效果。由于CAR-T细胞在实体瘤中的浸润能力相对较差，目前临床主要应用于血液肿瘤中。随着技术进展，如通过提升CAR-T中对增强T细胞浸润能力相关基因的表达，未来应该也能够在实体瘤治疗中发挥重要作用。TCR-T，又称T细胞识别受体（TCR）工程化改造T细胞治疗，是通过将对特定抗原亲和力强的TCR移植到患者自身的T细胞上使患者自身的T细胞发挥肿瘤细胞杀伤效果。其中特异性TCR-T，是指针对患者特异的新抗原进行设计的TCR-T治疗方式，是未来最有价值的癌症治疗手段，相比通过个性化疫苗诱导形成肿瘤杀伤T细胞，从原理上来说，特异性TCR-T治疗属于更靠后的免疫周期中的环节，可能具有更好的治疗效果。
                </p>
                <div class="display-aw">
                    <section style="font-size: 14px;width: 50%;padding-top: 140px;">
                        <p> ·4）溶瘤病毒</p>
                        <p>
                            溶瘤病毒是一群倾向于感染和杀伤肿瘤细胞的病毒。溶瘤病毒治疗是指将本身对身体伤害较低的溶瘤病毒经工程化改造减毒处理和治疗效果提升后，感染肿瘤患者的治疗方式。这种治疗思路和方法，是多年前发现和临床实践过的方法，且2005年中国CFDA批准了一种溶瘤腺病毒。但是，单药治疗效果有限，并未引起广泛关注。随着PD1抗体治疗的普及，临床研究发现，溶瘤病毒联合PD1治疗能够大幅度提高PD1抗体治疗的有效率，2015年，溶瘤病毒治疗T-Vec批准用于黑色素瘤。溶瘤病毒在提高PDL1表达、逆转肿瘤相关免疫抑制等多个层面，均能够与PD1抗体治疗形成非常好的协同效果。
                        </p>
                    </section>
                    <section>
                        <img style="width: 600px;" src="./img/680/img9.png" alt="">
                    </section>
                </div>

            </section>

            <section class="main-part part3">

                <h2 id="m3">三、化学治疗提示</h2>
                <h4> ·化疗药物检测结果</h4>
                <div class="table-680-1" style="width: 100%;">
                    <table style="width: 100%;" border="1">
                        <tr style="background: rgb(233,233,233);line-height: 30px;">
                            <th style="width: 46%;">化疗药物</th>
                            <th tyle="width: 18%;">敏感性</th>
                            <th tyle="width: 18%;">毒副作用</th>
                            <th tyle="width: 18%;">检测结果</th>

                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>铂类</td>
                            <td>较高</td>
                            <td>较低</td>
                            <td class="red">推荐使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>顺铂</td>
                            <td>较高</td>
                            <td>较低</td>
                            <td class="red">推荐使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>卡铂</td>
                            <td>较高</td>
                            <td>较低</td>
                            <td class="red">推荐使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>奥沙利铂</td>
                            <td>较高</td>
                            <td>较低</td>
                            <td class="red">推荐使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>培美曲塞</td>
                            <td>较低</td>
                            <td>-</td>
                            <td>谨慎使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>吉西他滨</td>
                            <td>-</td>
                            <td>居中</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>长春新碱</td>
                            <td>居中</td>
                            <td>-</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>紫杉醇</td>
                            <td>居中</td>
                            <td>较低</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>多西他赛（即多西紫杉醇）</td>
                            <td>-</td>
                            <td>较低</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>紫杉烷类化合物</td>
                            <td>较低</td>
                            <td>较低</td>
                            <td >谨慎使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>氟尿嘧啶</td>
                            <td>较低</td>
                            <td>较低</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>伊立替康</td>
                            <td>-</td>
                            <td>居中</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>依托泊苷</td>
                            <td>较高</td>
                            <td>较高</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>甲氨蝶呤</td>
                            <td>较高</td>
                            <td>居中</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>替加氟</td>
                            <td>较低</td>
                            <td>较低</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>嘧啶类似物</td>
                            <td>较低</td>
                            <td>较低</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>蒽环类</td>
                            <td>居中</td>
                            <td>-</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>他莫昔芬</td>
                            <td>居中</td>
                            <td>-</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>铂类化合物联合依托泊苷</td>
                            <td>-</td>
                            <td>较高</td>
                            <td>谨慎使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>顺铂联合紫杉醇</td>
                            <td>较高</td>
                            <td>较低</td>
                            <td class="red">推荐使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>顺铂联合环磷酰胺</td>
                            <td>较低</td>
                            <td>居中</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>氟尿嘧啶联合奥沙利铂</td>
                            <td>居中</td>
                            <td>-</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>FOLFOX</td>
                            <td>居中</td>
                            <td>居中</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>甲酰四氢叶酸联合替加氟或联合氟尿嘧啶</td>
                            <td>-</td>
                            <td>较低</td>
                            <td class="blue">常规使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>铂类联合多西紫杉醇，吉西他滨，紫杉醇或长春瑞滨</td>
                            <td>-</td>
                            <td>-</td>
                            <td class="blue">谨慎使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;">
                            <td>环磷酰胺联合表柔比星</td>
                            <td>较高</td>
                            <td>较低</td>
                            <td class="red">推荐使用</td>
                        </tr>
                        <tr style="line-height: 30px;text-align: center;font-weight: bold;background: rgb(233,233,233);">
                            <td colspan="4"> 说明</td>
                        </tr>
                        <tr >
                            <td colspan="4" style="padding: 10px; font-size: 14px;">
                                <p>1. 疗效预测（药物敏感性较高/低和毒副作用风险较高/低）根据证据等级综合判断获得。</p>
                                <p>2. 此处检测结果不具有临床医嘱性质，仅供临床医师参考，不作为直接用药依据，具体用药方案请遵医嘱。</p>
                                <p>3. “-”表示没有药物敏感性位点或毒副作用位点等的相关资料，不进行临床指导。</p>
                            </td>
                        </tr>
                    </table>
                </div>  
                <h4> ·化疗药物检测详细结果</h4>
                <div class="table-680-1" style="width: 100%;">
                    <table style="width: 100%;" border="1">
                        <tr style="line-height: 30px;text-align: center;background: rgb(233,233,233);">
                            <th style="width: 10%;">化疗药物</th>
                            <th style="width: 10%;">基因名称</th>
                            <th style="width: 10%;">检测位点</th>
                            <th style="width: 20%;">疾病</th>
                            <th style="width: 10%;">检测结果</th>
                            <th style="width: 20%;">判断结果</th>
                            <th style="width: 10%;">等级</th>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="6">铂类</td>
                            <td>NQO1</td>
                            <td>rs1800566</td>
                            <td>乳腺癌，非小细胞肺癌，卵巢癌，胃癌</td>
                            <td>AG</td>
                            <td>药物敏感性可能居中</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>XRCC1</td>
                            <td>rs25487</td>
                            <td>非小细胞肺癌，结直肠癌，卵巢癌，胰腺癌，宫颈癌</td>
                            <td>CC</td>
                            <td>药物敏感性可能较高</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>ERCC2</td>
                            <td>rs1799793</td>
                            <td>癌，非小细胞肺癌</td>
                            <td>CC</td>
                            <td>肺炎风险可能降低</td>
                            <td>3</td>
                        </tr>
                        
                        <tr style="text-align: center;">
                            <td>ERCC2</td>
                            <td>rs13181</td>
                            <td>非小细胞肺癌</td>
                            <td>GT</td>
                            <td>发生肺炎的风险可能降低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>ERCC1</td>
                            <td>rs11615</td>
                            <td>非小细胞肺癌，结肠直肠癌，食管癌，间皮瘤，卵巢癌，胰腺癌</td>
                            <td>GG</td>
                            <td>肾毒性风险可能降低；药物敏感性较好；存活率可能增加</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>GSTP1</td>
                            <td>rs1695</td>
                            <td>结直肠癌，非小细胞肺癌，卵巢癌</td>
                            <td>AG</td>
                            <td>药物毒性可能较高</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="8">顺铂</td>
                            <td>GSTP1</td>
                            <td>rs1695</td>
                            <td>髓母细胞瘤，睾丸癌</td>
                            <td>AG</td>
                            <td>耳毒性的风险可能更高</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>TPMT</td>
                            <td>rs1142345</td>
                            <td>肿瘤</td>
                            <td>TT</td>
                            <td>儿童听力丧失风险可能降低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>MTHFR</td>
                            <td>rs1801133</td>
                            <td>非小细胞肺癌，骨肉瘤</td>
                            <td>AG</td>
                            <td>药物敏感性可能较低，毒副作用风险可能降低</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>ERCC1</td>
                            <td>rs3212986</td>
                            <td>卵巢癌</td>
                            <td>AA</td>
                            <td>肾毒性风险可能降低</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>XPC</td>
                            <td>rs2228001</td>
                            <td>骨肉瘤，睾丸癌，膀胱癌</td>
                            <td>GG</td>
                            <td>毒副作用风险可能增加（听力丧失、中性细胞减少症）</td>
                            <td>1B</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>ACYP2</td>
                            <td>rs1872328</td>
                            <td>脑肿瘤</td>
                            <td>GG</td>
                            <td>耳毒性风险可能降低</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>XRCC1</td>
                            <td>rs25487</td>
                            <td>非小细胞肺癌，结直肠癌，卵巢癌，胰腺癌，宫颈癌</td>
                            <td>CC</td>
                            <td>药物敏感性可能较高</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>ERCC1</td>
                            <td>rs11615</td>
                            <td>非小细胞肺癌，结肠直肠癌，食管癌，间皮瘤，卵巢癌，胰腺癌</td>
                            <td>GG</td>
                            <td>肾毒性风险可能降低；药物敏感性较好；存活率可能增加</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="3">卡铂</td>
                            <td>ERCC1</td>
                            <td>rs11615</td>
                            <td>非小细胞肺癌，结肠直肠癌，食管癌，间皮瘤，卵巢癌，胰腺癌</td>
                            <td>GG</td>
                            <td>肾毒性风险可能降低；药物敏感性较好；存活率可能增加</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>XRCC1</td>
                            <td>rs25487</td>
                            <td>非小细胞肺癌，结直肠癌，卵巢癌，胰腺癌，宫颈癌</td>
                            <td>CC</td>
                            <td>药物敏感性可能较高</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>MTHFR</td>
                            <td>rs1801133</td>
                            <td>非小细胞肺癌，骨肉瘤</td>
                            <td>AG</td>
                            <td>药物敏感性可能较低，毒副作用风险可能降低</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="2">奥沙利铂</td>
                            <td>XRCC1</td>
                            <td>rs25487</td>
                            <td>非小细胞肺癌，结直肠癌，卵巢癌，胰腺癌，宫颈癌</td>
                            <td>CC</td>
                            <td>药物敏感性可能较高</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>ERCC1</td>
                            <td>rs11615</td>
                            <td>非小细胞肺癌，结肠直肠癌，食管癌，间皮瘤，卵巢癌，胰腺癌</td>
                            <td>GG</td>
                            <td>肾毒性风险可能降低；药物敏感性可能较好；存活率可能增加</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="2">培美曲塞</td>
                            <td>MTHFR</td>
                            <td>rs1801133</td>
                            <td>非小细胞肺癌，间皮瘤</td>
                            <td>AG</td>
                            <td>药物敏感性可能较低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>TYMS</td>
                            <td>rs151264360</td>
                            <td>间皮瘤</td>
                            <td>AAGTTA/ <br> AAGTTA</td>
                            <td>药物敏感性可能较低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="3">吉西他滨</td>
                            <td>NT5C2</td>
                            <td>rs11598702</td>
                            <td>肿瘤</td>
                            <td>TT</td>
                            <td>毒副作用可能较高</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>CDA</td>
                            <td>rs2072671</td>
                            <td>非小细胞肺癌，间皮瘤，胰腺癌</td>
                            <td>AA</td>
                            <td>毒副作用可能较低（血液或胃肠道毒性）</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>RRM1</td>
                            <td>rs1042858</td>
                            <td>乳腺癌</td>
                            <td>AG</td>
                            <td>毒副风险可能较低（中性粒细胞减少症）</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td >长春新碱</td>
                            <td>ABCB1</td>
                            <td>rs10276036</td>
                            <td>骨肉瘤</td>
                            <td>CT</td>
                            <td>药物敏感性可能居中</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="2">紫杉醇</td>
                            <td>CYP2C8</td>
                            <td>rs11572080</td>
                            <td>神经毒性综合征</td>
                            <td>CC</td>
                            <td>神经毒性风险可能降低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>ABCB1</td>
                            <td>rs2032582</td>
                            <td>乳腺癌，卵巢癌</td>
                            <td>CA</td>
                            <td>药物敏感性可能居中</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="2">多西他赛（即多西紫杉醇）</td>
                            <td>CYP3A4</td>
                            <td>rs2740574</td>
                            <td>肿瘤，乳腺癌</td>
                            <td>TT</td>
                            <td>药物代谢可能较慢，输液相关反应副作用可能降低，神经毒性的风险可能会降低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>ERCC2</td>
                            <td>rs13181</td>
                            <td>乳腺癌</td>
                            <td>GT</td>
                            <td>可能降低了中性粒细胞减少的风险</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="2">紫杉烷类化合物</td>
                            <td>ABCB1</td>
                            <td>rs1045642</td>
                            <td>乳腺癌</td>
                            <td>AG</td>
                            <td>药物敏感性可能较低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>ABCB1</td>
                            <td>rs2032582</td>
                            <td>卵巢癌</td>
                            <td>AC</td>
                            <td>可能增加胃肠道毒性的风险</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="11">氟尿嘧啶</td>
                            <td>DPYD</td>
                            <td>rs55886062</td>
                            <td>肿瘤</td>
                            <td>AA</td>
                            <td>药物毒性风险可能降低</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>TYMS</td>
                            <td>rs151264360</td>
                            <td>结直肠肿瘤</td>
                            <td>AAGTTA/ <br> AAGTTA</td>
                            <td>药物敏感性可能较低；药物毒性风险可能降低</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>DPYD</td>
                            <td>rs72549303</td>
                            <td>先天性嘌呤嘧啶代谢缺陷</td>
                            <td>GG</td>
                            <td>DPYD活性可能增加</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>DPYD</td>
                            <td>rs3918290</td>
                            <td>结直肠癌</td>
                            <td>CC</td>
                            <td>药物代谢可能较快；药物毒性风险可能降低</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>DPYD</td>
                            <td>rs115232898</td>
                            <td>结直肠癌，肿瘤</td>
                            <td>TT</td>
                            <td>药物毒性风险可能降低；DPYD活性可能增加</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>DPYD</td>
                            <td>rs1801159</td>
                            <td>肿瘤</td>
                            <td>CC</td>
                            <td>毒副作用可能增加（恶心，呕吐和白细胞减少）；药物敏感性可能较低；药物代谢可能较慢</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>NQO1</td>
                            <td>rs1800566</td>
                            <td>乳腺癌，非小细胞肺癌，卵巢癌，胃癌</td>
                            <td>AG</td>
                            <td>药物敏感性可能居中</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>DPYD</td>
                            <td>rs1801265</td>
                            <td>肿瘤</td>
                            <td>AG</td>
                            <td>药物毒性风险可能增加；药物敏感性可能较低；药物代谢可能较快；DPYD活性可能增加</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>DPYD</td>
                            <td>rs75017182</td>
                            <td>结直肠癌，肿瘤</td>
                            <td>GG</td>
                            <td>药物毒性风险可能降低；剂量可能需要降低</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>DPYD</td>
                            <td>rs72549309</td>
                            <td>先天性嘌呤嘧啶代谢缺陷</td>
                            <td>ATGA/ATGA</td>
                            <td>DPYD活性可能增加</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>DPYD</td>
                            <td>rs67376798</td>
                            <td>结直肠癌等肿瘤</td>
                            <td>TT</td>
                            <td>药物代谢可能较快；药物毒性风险可能降低（腹泻）</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="3">伊立替康</td>
                            <td>UGT1A1</td>
                            <td>rs4148323</td>
                            <td>非小细胞肺癌，肿瘤</td>
                            <td>AG</td>
                            <td>中性粒细胞减少症风险可能居中</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                          
                            <td>SEMA3C</td>
                            <td>rs7779029</td>
                            <td>非小细胞肺癌</td>
                            <td>TT</td>
                            <td>中性粒细胞减少症风险可能降低</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                          
                            <td>UGT1A1</td>
                            <td>rs8175347</td>
                            <td>肿瘤</td>
                            <td>(TA)7 / (TA)7</td>
                            <td>药物毒性风险可能增加（中性粒细胞减少，腹泻或乏力）</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="2">依托泊苷</td>
                            <td>SLCO1B1</td>
                            <td>rs2291075</td>
                            <td>急性髓性白血病</td>
                            <td>CT</td>
                            <td>药物敏感性可能较高</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            
                            <td>ABCB1</td>
                            <td>rs1045642</td>
                            <td>白血病，淋巴瘤</td>
                            <td>AG</td>
                            <td>药物代谢可能较慢</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="5">甲氨蝶呤</td>
                            <td>ABCB1</td>
                            <td>rs1045642</td>
                            <td>白血病，淋巴瘤</td>
                            <td>AG</td>
                            <td>毒性风险可能居中</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>ATIC</td>
                            <td>rs4673993</td>
                            <td>类风湿关节炎</td>
                            <td>CT</td>
                            <td>药物敏感性可能居中</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>MTRR</td>
                            <td>rs1801394</td>
                            <td>白血病，淋巴瘤</td>
                            <td>AG</td>
                            <td>毒性风险可能较高（口腔粘膜炎）；血小板恢复速度加快；淋巴母细胞中TYMS反应和催化活性增强</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>MTHFR</td>
                            <td>rs1801133</td>
                            <td>类风湿关节炎</td>
                            <td>CT</td>
                            <td>药物敏感性可能居中；毒性风险可能居中；所需剂量可能居中</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>DHFR</td>
                            <td>rs1650723</td>
                            <td>骨肉瘤</td>
                            <td>CC</td>
                            <td>粘膜炎的严重性可能降低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="4">替加氟</td>
                            <td>DPYD</td>
                            <td>rs3918290</td>
                            <td>结直肠癌</td>
                            <td>CC</td>
                            <td>药物代谢可能较快；药物毒性风险可能降低</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                          
                            <td>DPYD</td>
                            <td>rs67376798</td>
                            <td>结直肠癌等肿瘤</td>
                            <td>TT</td>
                            <td>药物代谢可能较快；药物毒性风险可能降低（腹泻）</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                          
                            <td>DPYD</td>
                            <td>rs1801159</td>
                            <td>肿瘤</td>
                            <td>CC</td>
                            <td>毒副作用可能增加（恶心，呕吐和白细胞减少）；药物敏感性可能较低；药物代谢可能较慢</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                          
                            <td>DPYD</td>
                            <td>rs55886062</td>
                            <td>肿瘤</td>
                            <td>AA</td>
                            <td>药物毒性风险可能降低</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="4">嘧啶类似物</td>
                            <td>DPYD</td>
                            <td>rs55886062</td>
                            <td>肿瘤</td>
                            <td>AA</td>
                            <td>药物毒性风险可能降低</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                          
                            <td>DPYD</td>
                            <td>rs3918290</td>
                            <td>结直肠癌</td>
                            <td>CC</td>
                            <td>药物代谢可能较快；药物毒性风险可能降低</td>
                            <td>1A</td>
                        </tr>
                        <tr style="text-align: center;">
                          
                            <td>DPYD</td>
                            <td>rs1801159</td>
                            <td>肿瘤</td>
                            <td>CC</td>
                            <td>毒副作用可能增加（恶心，呕吐和白细胞减少）；药物敏感性可能较低；药物代谢可能较慢</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                          
                            <td>DPYD</td>
                            <td>rs67376798</td>
                            <td>结直肠癌等肿瘤</td>
                            <td>TT</td>
                            <td>毒副作用可能增加（恶心，呕吐和白细胞减少）；药物敏感性可能较低；药物代谢可能较慢</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>蒽环类</td>
                            <td>NQO1</td>
                            <td>rs1800566</td>
                            <td>乳腺癌，非小细胞肺癌，卵巢癌，胃癌</td>
                            <td>AG</td>
                            <td>药物敏感性可能居中</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>他莫昔芬</td>
                            <td>CYP19A1</td>
                            <td>rs4646</td>
                            <td>乳腺癌</td>
                            <td>AC</td>
                            <td>绝经前女性药物疗效可能较差，绝经后女性药物疗效可能较好</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>铂类化合物联合依托泊苷</td>
                            <td>DYNC2H1</td>
                            <td>rs716274</td>
                            <td>小细胞肺癌</td>
                            <td>AG</td>
                            <td>药物毒副风险可能较高</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>顺铂联合紫杉醇</td>
                            <td>TP53</td>
                            <td>rs1042522</td>
                            <td>胃癌</td>
                            <td>CC</td>
                            <td>药物敏感性可能较好；毒性风险可能有所降低</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="2">顺铂联合环磷酰胺</td>
                            <td>ERCC1</td>
                            <td>rs3212986</td>
                            <td>卵巢癌</td>
                            <td>AA</td>
                            <td>肾毒性风险可能降低</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                          
                            <td>TP53</td>
                            <td>rs1042522</td>
                            <td>卵巢癌</td>
                            <td>CC</td>
                            <td>药物敏感性可能较差；毒性风险可能增加</td>
                            <td>2B</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>氟尿嘧啶联合奥沙利铂</td>
                            <td>GSTP1</td>
                            <td>rs1695</td>
                            <td>结直肠癌，胃癌</td>
                            <td>AG</td>
                            <td>药物敏感性可能居中</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td rowspan="4">FOLFOX</td>
                            <td>ABCC2</td>
                            <td>rs717620</td>
                            <td>结直肠癌</td>
                            <td>CC</td>
                            <td>神经毒性综合征风险可能降低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>ERCC1</td>
                            <td>rs11615</td>
                            <td>结直肠癌</td>
                            <td>GG</td>
                            <td>药物敏感性可能较高；中性粒细胞减少症副作用可能较低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>MTHFR</td>
                            <td>rs1801133</td>
                            <td>结肠癌</td>
                            <td>AG</td>
                            <td>药物敏感性可能较低</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                           
                            <td>ERCC2</td>
                            <td>rs13181</td>
                            <td>结肠直肠癌</td>
                            <td>GT</td>
                            <td>药物毒性风险可能增加；药物敏感性可能居中</td>
                            <td>3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>甲酰四氢叶酸联合替加氟或联合氟尿嘧啶</td>
                            <td>UMPS</td>
                            <td>rs1801019</td>
                            <td>腺癌，结直肠癌</td>
                            <td>GG</td>
                            <td>毒性风险可能降低（腹泻，任何3级不良事件）</td>
                            <td>2B</td>
                        </tr>

                        <tr style="text-align: center;">
                            <td>环磷酰胺联合表柔比星</td>
                            <td>GSTP1</td>
                            <td>rs1695</td>
                            <td>乳腺癌</td>
                            <td>AG</td>
                            <td>药敏敏感性可能增加；药物毒性可能降低</td>
                            <td>2A</td>
                        </tr>
                        <tr style="text-align: center;line-height: 30px;font-weight: bold;background: rgb(233,233,233);">
                            <td colspan="7" >
                                说明
                            </td>
                        </tr>
                        <tr>
                            <td colspan="7" style="position: relative;padding: 10px;">
                                <img style="position: absolute;right: 0;top: 0;" src="./img/680/img10.png" alt="">
                                <p>1. 基因名称：均采用 HGNC 里的官方命名。</p>
                                <p>2. rs 号：NCBI 里对所提交的 snp 给予的编号。</p>
                                <p>3. 对应疾病：为 PharmGKB 数据库中相关药物的对应疾病研究。</p>
                                <p>4. 等级划分：参考https://www.pharmgkb.org/page/clinAnnLevels。</p>
                                <p style="padding-left: 40px;">
                                    1A：注释基于被医学会认可的指南或经某些重大卫生系统的认可；
                                </p>
                                <p style="padding-left: 40px;">
                                    1B：注释基于多项有统计显著的研究；
                                </p>
                                <p style="padding-left: 40px;">
                                    2A：注释基于多项重复研究，故药效关系很有可能是有意义的；
                                </p>
                                <p style="padding-left: 40px;">
                                    3：注释仅基于 1 项有显著差异的研究（未重复）或多项研究但缺乏明显药效关联性；
                                </p>
                                <p style="padding-left: 40px;">
                                    4：注释仅基于少量病例、非权威研究或体外的分子功能研究。
                                </p>
                                <p>
                                    5. 检测结果只对本次送检样品负责，样品只进行 DNA 水平检测，不涉及 RNA 和蛋白质水平。
                                </p>
                                <p>6. 检测结果不具有临床医嘱性质，仅供临床医师参考。</p>
                                <p>7. 如对报告有疑义，请在收到报告后 7 个工作日内与我们联系。</p>
                            </td>
                        </tr>

                    
                    </table>
                </div>

            </section>

            <section class="main-part part4">
                <h2 id="m4">四、肿瘤遗传性检测结果</h2>

                <div class="table-680-1" style="width: 100%;">
                    <table border="1" style="width:100%">
                        <tr style="line-height: 30px;font-weight: 500;">
                            <th>· 在42种遗传性肿瘤综合征相关的162个基因中，未发现与遗传性肿瘤相关的明确致病突变位点</th>
                        </tr>
                        <tr style="line-height: 30px;">
                            <th> 遗传性肿瘤相关基因变异可能在该肿瘤的发生发展中扮演次要角色</th>
                        </tr>

                    </table>

                    <table border="1" style="width:100%;margin-top: 20px;"> 
                        <tr style="display: none;">
                            <th style="width: 25%;"></th>
                            <th style="width: 25%;"></th>
                            <th style="width: 25%;"></th>
                            <th style="width: 25%;"></th>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td>共济失调性毛细血管扩张症</td>
                            <td>自身免疫性淋巴增生综合征</td>
                            <td>巨舌巨人综合征</td>
                            <td class="red">Birt-Hogg-Dubé综合征</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td>Bloom综合征</td>
                            <td>Carney综合征</td>
                            <td class="red">Cowden综合征</td>
                            <td class="red">Diamond-Wiedemann贫血症</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td>家族性腺瘤性息肉病</td>
                            <td>家族性胃肠道间质瘤</td>
                            <td class="red">Fanconi贫血</td>
                            <td>遗传性乳腺癌-卵巢癌综合征</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td>遗传性弥漫型胃癌</td>
                            <td>遗传性平滑肌瘤病肾癌</td>
                            <td>遗传性多发性骨软骨瘤</td>
                            <td>遗传性乳头状肾细胞癌</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td>遗传性前列腺癌</td>
                            <td>Howell-Evans综合征</td>
                            <td>甲状旁腺机能亢进-颌骨肿瘤综合征</td>
                            <td>幼年性息肉病综合征</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td class="red">Li-Fraumeni综合征</td>
                            <td>Lynch综合征</td>
                            <td>皮肤恶性黑色素瘤</td>
                            <td>多发性内分泌腺瘤病1型</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td>多发性内分泌腺瘤病2型</td>
                            <td>MUTYH相关性息肉病</td>
                            <td>家族性神经母细胞瘤</td>
                            <td>神经纤维瘤病1型</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td>神经纤维瘤病2型</td>
                            <td>痣样基底细胞癌综合症</td>
                            <td class="red">Nijmegen断裂综合征</td>
                            <td>遗传性副神经节瘤-嗜铬细胞瘤综合征</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td class="red">Peutz-Jeghers综合征</td>
                            <td>PTEN错构瘤综合征</td>
                            <td>遗传性视网膜母细胞瘤</td>
                            <td class="red">Rothmund-Thomson综合征</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td>结节性硬化症</td>
                            <td class="red">Turcot综合征</td>
                            <td class="red">von Hippel-Lindau综合征</td>
                            <td class="red">Werner综合征（成人早衰症）</td>
                        </tr>
                        <tr style="text-align: center;line-height: 40px;">
                            <td>家族性肾母细胞瘤</td>
                            <td>着色性干皮病</td>
                            <td></td>
                            <td></td>
                        </tr>
                    </table>
                </div>
                <p style="font-size: 14px;"> <span class="red">红色</span>，表示该遗传性肿瘤综合征相关基因具有明确致病突变位点 </p>
            </section>

            <section class="main-part part5">
                <h2 id="m5">五、基因突变检测结果汇总</h2>
                <div class="table-680-1" style="width: 100%;">
                    <table border="1" style="width: 100%;">
                        <tr style="line-height: 30px;color: white;background:rgb(65,175,150);" id="m5-1">
                            <th colspan="8">体细胞突变</th>
                        </tr>
                        <tr style="line-height: 30px;">
                            <th>基因</th>
                            <th>核苷酸变化</th>
                            <th>氨基酸变化</th>
                            <th>外显子</th>
                            <th>变异类型</th>
                            <th>突变丰度</th>
                            <th>覆盖度</th>
                            <th>Cosmic计数</th>
                        </tr>
                        <tr style="text-align: center;">
                            <td>EGFR</td>
                            <td>c.2573T＞G</td>
                            <td>p.L858R</td>
                            <td>Exon21</td>
                            <td>错义突变</td>
                            <td>11.76%</td>
                            <td>119x</td>
                            <td>10256</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>TP53</td>
                            <td>c.586C＞G</td>
                            <td>p.R196G</td>
                            <td>Exon6</td>
                            <td>错义突变</td>
                            <td>11.27%</td>
                            <td>142x</td>
                            <td>1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>CTNNB1</td>
                            <td>c.110C＞G</td>
                            <td>p.S37C</td>
                            <td>Exon3</td>
                            <td>错义突变</td>
                            <td>3.41%</td>
                            <td>264x</td>
                            <td>200</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>ATM</td>
                            <td>c.7330G＞A</td>
                            <td>p.E2444K</td>
                            <td>Exon50</td>
                            <td>错义突变</td>
                            <td>6.34%</td>
                            <td>489x</td>
                            <td>4</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>AR</td>
                            <td>c.2197G＞A</td>
                            <td>p.D733N</td>
                            <td>Exon5</td>
                            <td>错义突变</td>
                            <td>6.36%</td>
                            <td>173x</td>
                            <td>2</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>CXCR4</td>
                            <td>c.53C＞A</td>
                            <td>p.S18*</td>
                            <td>Exon2</td>
                            <td>终止突变</td>
                            <td>5.5%</td>
                            <td>654x</td>
                            <td>1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>FAT1</td>
                            <td>c.7324A＞T</td>
                            <td>p.S2442C</td>
                            <td>Exon10</td>
                            <td>错义突变</td>
                            <td>5.1%</td>
                            <td>294x</td>
                            <td>1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>EGFR</td>
                            <td>c.3562A＞T</td>
                            <td>p.K1188*</td>
                            <td>Exon28</td>
                            <td>终止突变</td>
                            <td>4.52%</td>
                            <td>199x</td>
                            <td>1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>TMPRSS2</td>
                            <td>c.40G＞A</td>
                            <td>p.E14K</td>
                            <td>Exon1</td>
                            <td>错义突变</td>
                            <td>13.04%</td>
                            <td>46x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>JAK2</td>
                            <td>c.226+6T＞C</td>
                            <td></td>
                            <td>Exon</td>
                            <td>剪切区域突变</td>
                            <td>13.02%</td>
                            <td>361x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>JAK2</td>
                            <td>c.226+6T＞C</td>
                            <td></td>
                            <td>Exon</td>
                            <td>剪切区域突变</td>
                            <td>13.02%</td>
                            <td>361x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>JAK2</td>
                            <td>c.226+6T＞C</td>
                            <td></td>
                            <td>Exon</td>
                            <td>剪切区域突变</td>
                            <td>13.02%</td>
                            <td>361x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>PDGFRA</td>
                            <td>c.2333T＞C</td>
                            <td>p.V778A</td>
                            <td>Exon17</td>
                            <td>错义突变</td>
                            <td>12.44%</td>
                            <td>193x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>AKT1</td>
                            <td>c.1402C＞A</td>
                            <td>p.H468N</td>
                            <td>Exon15</td>
                            <td>错义突变</td>
                            <td>12.0%</td>
                            <td>100x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>NOTCH1</td>
                            <td>c.4683T＞G</td>
                            <td>p.C1561W</td>
                            <td>Exon26</td>
                            <td>错义突变</td>
                            <td>11.32%</td>
                            <td>53x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>POLE</td>
                            <td>c.4005G＞A</td>
                            <td>p.Q1335=</td>
                            <td>Exon31</td>
                            <td>剪切区域突变</td>
                            <td>10.39%</td>
                            <td>77x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>STK11</td>
                            <td>c.626C＞G</td>
                            <td>p.T209S</td>
                            <td>Exon5</td>
                            <td>错义突变</td>
                            <td>10.17%</td>
                            <td>59x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>INPP4B</td>
                            <td>c.2453G＞C</td>
                            <td>p.R818T</td>
                            <td>Exon22</td>
                            <td>错义突变</td>
                            <td>9.63%</td>
                            <td>987x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>STAG2</td>
                            <td>c.1210G＞A</td>
                            <td>p.V404I</td>
                            <td>Exon14</td>
                            <td>错义突变</td>
                            <td>9.21%</td>
                            <td>608x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>BRAF</td>
                            <td>c.138+8C＞T</td>
                            <td></td>
                            <td>Exon</td>
                            <td>剪切区域突变</td>
                            <td>8.93%</td>
                            <td>56x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>BRAF</td>
                            <td>c.138+8C＞T</td>
                            <td></td>
                            <td>Exon</td>
                            <td>剪切区域突变</td>
                            <td>8.93%</td>
                            <td>56x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>PDGFRB</td>
                            <td>c.3071C＞A</td>
                            <td>p.P1024H</td>
                            <td>Exon22</td>
                            <td>错义突变</td>
                            <td>8.72%</td>
                            <td>149x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>FANCA</td>
                            <td>c.3522G＞A</td>
                            <td>p.W1174*</td>
                            <td>Exon36</td>
                            <td>终止突变</td>
                            <td>8.7%</td>
                            <td>69x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>POLD1</td>
                            <td>c.1138G＞A</td>
                            <td>p.A380T</td>
                            <td>Exon10</td>
                            <td>错义突变</td>
                            <td>8.33%</td>
                            <td>60x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>RASA1</td>
                            <td>c.47C＞T</td>
                            <td>p.A16V</td>
                            <td>Exon1</td>
                            <td>错义突变</td>
                            <td>8.0%</td>
                            <td>50x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>NOTCH2</td>
                            <td>c.1054A＞C</td>
                            <td>p.T352P</td>
                            <td>Exon6</td>
                            <td>错义突变</td>
                            <td>7.28%</td>
                            <td>206x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>MPL</td>
                            <td>c.1333C＞T</td>
                            <td>p.R445*</td>
                            <td>Exon9</td>
                            <td>终止突变</td>
                            <td>7.23%</td>
                            <td>83x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>ALK</td>
                            <td>c.3190C＞T</td>
                            <td>p.Q1064*</td>
                            <td>Exon20</td>
                            <td>终止突变</td>
                            <td>7.14%</td>
                            <td>140x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>SMAD4</td>
                            <td>c.322G＞A</td>
                            <td>p.E108K</td>
                            <td>Exon3</td>
                            <td>错义突变</td>
                            <td>6.93%</td>
                            <td>548x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>ABL1</td>
                            <td>c.1912G＞T</td>
                            <td>p.G638C</td>
                            <td>Exon11</td>
                            <td>错义突变</td>
                            <td>6.9%</td>
                            <td>87x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>RET</td>
                            <td>c.2589G＞T</td>
                            <td>p.Q863H</td>
                            <td>Exon14</td>
                            <td>错义突变</td>
                            <td>6.76%</td>
                            <td>74x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>EGFR</td>
                            <td>c.3244A＞T</td>
                            <td>p.I1082L</td>
                            <td>Exon27</td>
                            <td>错义突变</td>
                            <td>6.62%</td>
                            <td>136x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>KMT2A</td>
                            <td>c.2977A＞T</td>
                            <td>p.T993S</td>
                            <td>Exon3</td>
                            <td>错义突变</td>
                            <td>6.61%</td>
                            <td>227x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>POLD1</td>
                            <td>c.2717+7C＞T</td>
                            <td></td>
                            <td>Exon</td>
                            <td>剪切区域突变</td>
                            <td>6.35%</td>
                            <td>63x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>KIT</td>
                            <td>c.1604T＞G</td>
                            <td>p.M535R</td>
                            <td>Exon10</td>
                            <td>错义突变</td>
                            <td>6.28%</td>
                            <td>446x</td>
                            <td>0</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>MYD88</td>
                            <td>c.254G＞C</td>
                            <td>p.G85A</td>
                            <td>Exon1</td>
                            <td>错义突变</td>
                            <td>6.25%</td>
                            <td>64x</td>
                            <td>0</td>
                        </tr>
                    </table>

                    <table border="1" style="width: 100%;margin-top: 20px;">
                        <tr style="background: rgb(65,175,150);color: #fff;line-height: 40px;">
                            <th colspan="8" id="m5-3">重点基因拷贝数检测结果</th>
                        </tr>
                        <tr style="text-align: center;">
                            <td>MEF2B</td>
                            <td>FGF4</td>
                            <td>KEAP1</td>
                            <td>ESR1</td>
                            <td>MAPK1</td>
                            <td>TSC2</td>
                            <td>MGA</td>
                            <td>AGO2</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>PIK3R2</td>
                            <td>CCND1</td>
                            <td>GLI1</td>
                            <td>CDKN1B</td>
                            <td>MLH1</td>
                            <td>BCL6</td>
                            <td>MSH2</td>
                            <td>MSH6</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>TNFAIP3</td>
                            <td>DUSP4</td>
                            <td>CXCR4</td>
                            <td>FLT3</td>
                            <td>CDKN1A</td>
                            <td>SOX9</td>
                            <td>SMO</td>
                            <td>FOXA1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>RAF1</td>
                            <td>LATS1</td>
                            <td>BTG1</td>
                            <td>KRAS</td>
                            <td>VHL</td>
                            <td>PDGFRA</td>
                            <td>APC</td>
                            <td>HNF1A</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>CDK4</td>
                            <td>BRIP1</td>
                            <td>FGFR3</td>
                            <td>BARD1</td>
                            <td>CCND2</td>
                            <td>CDH1</td>
                            <td>PDGFRB</td>
                            <td>SMAD2</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>RHEB</td>
                            <td>KMT2C</td>
                            <td>AXIN1</td>
                            <td>CREBBP</td>
                            <td>CCNE1</td>
                            <td>CDKN2C</td>
                            <td>INPP4B</td>
                            <td>SMARCB1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>EP300</td>
                            <td>EED</td>
                            <td>BRD4</td>
                            <td>AKT3</td>
                            <td>KDR</td>
                            <td>PIK3CA</td>
                            <td>CTCF</td>
                            <td>CBL</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>DNMT3A</td>
                            <td>MSH3</td>
                            <td>RAD50</td>
                            <td>CDK6</td>
                            <td>PMS2</td>
                            <td>ERBB3</td>
                            <td>RB1</td>
                            <td>TP53</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>ERBB2</td>
                            <td>PIK3R1</td>
                            <td>RASA1</td>
                            <td>EGFR</td>
                            <td>CDKN2B</td>
                            <td>NOTCH1</td>
                            <td>ATM</td>
                            <td>MYCN</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>FBXW7</td>
                            <td>FLT1</td>
                            <td>YAP1</td>
                            <td>KIT</td>
                            <td>BRAF</td>
                            <td>PIK3CB</td>
                            <td>FGFR4</td>
                            <td>FGF19</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>NPM1</td>
                            <td>SOX17</td>
                            <td>RAD21</td>
                            <td>TSC1</td>
                            <td>RUNX1</td>
                            <td>ANKRD11</td>
                            <td>KMT2D</td>
                            <td>AXL</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>CDKN2A</td>
                            <td>PPM1D</td>
                            <td>MAP2K1</td>
                            <td>BCL2L1</td>
                            <td>TERT</td>
                            <td>HRAS</td>
                            <td>ERCC4</td>
                            <td>AURKA</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>WHSC1L1</td>
                            <td>EZH2</td>
                            <td>CIITA</td>
                            <td>ARID1A</td>
                            <td>SHQ1</td>
                            <td>STK11</td>
                            <td>SMAD3</td>
                            <td>DNMT3B</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>RBM10</td>
                            <td>IKZF1</td>
                            <td>FGF3</td>
                            <td>ARID2</td>
                            <td>EPHA3</td>
                            <td>MEN1</td>
                            <td>NF2</td>
                            <td>SMAD4</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>DICER1</td>
                            <td>SMARCA4</td>
                            <td>ARID1B</td>
                            <td>GATA3</td>
                            <td>AKT1</td>
                            <td>PTPN11</td>
                            <td>MITF</td>
                            <td>NKX2-1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>RAC1</td>
                            <td>PAK1</td>
                            <td>PTPRD</td>
                            <td>BCL11B</td>
                            <td>RICTOR</td>
                            <td>BRCA1</td>
                            <td>PAX5</td>
                            <td>SRC</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>NF1</td>
                            <td>CASP8</td>
                            <td>FGFR2</td>
                            <td>MAX</td>
                            <td>TGFBR2</td>
                            <td>XRCC2</td>
                            <td>FH</td>
                            <td>PARP1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>IKBKE</td>
                            <td>MDM4</td>
                            <td>CDC73</td>
                            <td>RFWD2</td>
                            <td>DDR2</td>
                            <td>ROS1</td>
                            <td>MCL1</td>
                            <td>PRDM1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>CD58</td>
                            <td>NRAS</td>
                            <td>BCL10</td>
                            <td>JUN</td>
                            <td>PTEN</td>
                            <td>CCND3</td>
                            <td>ATRX</td>
                            <td>TET1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>MED12</td>
                            <td>DAXX</td>
                            <td>AR</td>
                            <td>TGFBR1</td>
                            <td>SDHB</td>
                            <td>SDHD</td>
                            <td>ASXL1</td>
                            <td>ERRFI1</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>KDM6A</td>
                            <td>MYC</td>
                            <td>BCOR</td>
                            <td>TET2</td>
                            <td>BRCA2</td>
                            <td>MTAP</td>
                            <td>CDK8</td>
                            <td>CD274</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>JAK2</td>
                            <td>TP53BP1</td>
                            <td>LATS2</td>
                            <td>ALK</td>
                            <td>FANCA</td>
                            <td>ERCC2</td>
                            <td>AKT2</td>
                            <td>BCL2L11</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>PBRM1</td>
                            <td>CARD11</td>
                            <td>PDCD1LG2</td>
                            <td>MET</td>
                            <td>KDM5A</td>
                            <td>ETV1</td>
                            <td>SETD2</td>
                            <td>RHOA</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>FGFR1</td>
                            <td>RELN</td>
                            <td>ASXL2</td>
                            <td>FAT1</td>
                            <td>CDK12</td>
                            <td>BBC3</td>
                            <td>BAP1</td>
                            <td>MDM2</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>RAD51B</td>
                            <td>VEGFA</td>
                            <td>NTRK1</td>
                            <td>KMT2A</td>
                            <td>B2M</td>
                            <td>CIC</td>
                            <td>FOXP1</td>
                            <td>REL</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>NCOA3</td>
                            <td>TTF1</td>
                            <td>GSTP1</td>
                            <td>BIRC7</td>
                            <td>RSF1</td>
                            <td>TOP1</td>
                            <td>TYMS</td>
                            <td>ABCC3</td>
                        </tr>
                        <tr style="text-align: center;">
                            <td>ASNS</td>
                            <td>LRP1B</td>
                            <td>NTRK3</td>
                            <td>TLK2</td>
                            <td></td>
                            <td></td>
                            <td></td>
                            <td></td>
                        </tr>


                    </table>

                    <p style="font-size: 14px;"> <span  style="background: red;color: #fff;">红色</span>，表示该基因扩增；
                        <span  style="background: rgb(0, 25, 75);color: #fff;"> 深蓝色 </span>，表示该基因纯合缺失；
                        <span  style="background: rgb(54,95,245);color: #fff;">  淡蓝色  </span>，表示该基因杂合缺失，扩增缺失状态未达阈值用灰色表示
                    </p>

                    <table border="1" style="width: 100%;">
                        <tr style="line-height: 30px;color: white;background:rgb(65,175,150);">
                            <th colspan="7">拷贝数变异相关基因详细信息汇总</th>
                        </tr>
                        <tr style="line-height:40px;text-align: center;">
                            <td>基因</td>
                            <td>总拷贝数</td>
                            <td>低拷贝数</td>
                            <td>区域大小</td>
                            <td>WGD状态</td>
                            <td>基因组倍性</td>
                            <td>变异状态</td>
                        </tr>
                        <tr style="line-height:30px;text-align: center;">
                            <td>无</td>
                            <td>无</td>
                            <td>无</td>
                            <td>无</td>
                            <td>无</td>
                            <td>无</td>
                            <td>无</td>
                        </tr>
                    </table>

                    <p style="font-size: 14px;">注：肿瘤纯度低于30%时，二代测序拷贝数变异检测准确性会发生比较明显下降。</p>

                </div>
            </section>

            <section class="main-part part6">
                <h2 style="text-align: center;"> 附  录</h2>
                <h4 style="color:rgb(75,172,198)"> ·基因检测列表</h4>
                <h4 style="font-size: 14px;">573个基因全外显子（点突变、短片段拆入/缺失、拷贝数变异）</h4>
                <div class="table-680-1" style="width: 100%;">
                    <!-- <table border="1" style="width: 100%;">
                        <tr style="text-align: center;">
                            <td>ABL1</td>
                            <td>ACVR1</td>
                            <td>ACVR1B</td>
                            <td>ACVR2A</td>
                            <td>AGO2</td>
                            <td>AKT1</td>
                            <td>AKT2</td>
                            <td>AKT3</td>
                            <td>ALK</td>
                        
                        </tr>
                    </table> -->
                    <!-- 附录 -->
                    <div style="text-align:center">
                        <table cellspacing="0" cellpadding="0" style="border-collapse:collapse; margin:0 auto; width:100%" border="1">
                            <tbody>
                                <tr>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ABL1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ACVR1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ACVR1B</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ACVR2A</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AGO2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AKT1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AKT2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AKT3</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ALK</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ALOX12B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AMER1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ANKRD11</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">APC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ARAF</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ARFRP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ARID1A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ARID1B</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ARID2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ARID5B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ASXL1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ASXL2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ATM</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ATR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ATRX</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AURKA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AURKB</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AXIN1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AXIN2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">AXL</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">B2M</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BABAM1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BAP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BARD1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BBC3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCL10</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCL2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCL2L1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCL2L11</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCL2L2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCL6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCOR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCORL1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BIRC3</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BIRC5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BLK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BLM</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BMPR1A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BRAF</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BRCA1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BRCA2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BRD4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BRIP1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BTG1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BTK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">C11orf30</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CALR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CARD11</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CARM1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CASP8</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CBFB</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CBL</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CCND1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CCND2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CCND3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CCNE1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD19</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD22</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD274</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD276</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD38</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD3D</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD3E</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD3G</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD52</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD74</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD79A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD79B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDC42</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDC73</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDH1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDK12</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDK2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDK4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDK6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDK8</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDK9</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDKN1A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDKN1B</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDKN2A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDKN2B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDKN2C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CEBPA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CENPA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CHD4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CHEK1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CHEK2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CIC</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CREBBP</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CRKL</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CRLF2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CSDE1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CSF1R</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CSF3R</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CSK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CTCF</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CTLA4</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CTNNA1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CTNNB1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CUL3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CUL4A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CXCR4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYLD</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP2C8</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP2E1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYSLTR2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DAXX</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DCUN1D1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DDR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DDR2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DICER1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DIS3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DNAJB1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DNMT1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DNMT3A</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DNMT3B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DOT1L</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DROSHA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DUSP4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">E2F3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EED</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EGF</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EGFL7</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EGFR</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EIF1AX</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EIF4A2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EIF4E</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ELF3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EML4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EP300</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EPAS1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EPCAM</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EPHA2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EPHA3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EPHA5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EPHA7</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EPHB1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERBB2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERBB3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERBB4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERCC1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERCC2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERCC3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERCC4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERCC5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERF</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERG</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERRFI1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ESR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ETV1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ETV4</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ETV6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EWSR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EZH1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EZH2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EZR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FAM175A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FAM46C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FAM58A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FANCA</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FANCC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FANCD2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FANCE</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FANCF</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FANCG</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FANCI</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FANCL</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FAS</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FAT1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FBXW7</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF10</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF12</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF14</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF19</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF23</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF3</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF7</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF8</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGF9</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGFR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGFR2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGFR3</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGFR4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FH</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FLCN</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FLT1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FLT3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FLT4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FOXA1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FOXL2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FOXO1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FOXP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FUBP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FYN</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GABRA6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GATA1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GATA2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GATA3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GATA4</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GATA6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GID4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GLI1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GNA11</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GNA13</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GNAQ</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GNAS</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GPS2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GREM1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GRIN2A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GRM3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GSK3B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">H3F3A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">H3F3B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">H3F3C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HCK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HGF</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H1C</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H2BD</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3D</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3E</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3F</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3G</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3H</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3I</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST1H3J</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST2H3C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST2H3D</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HIST3H3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HLA-A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HLA-B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HNF1A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HOXB13</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HRAS</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HSD3B1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HSP90AA1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ICOSLG</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ID3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IDH1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IDH2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IFNGR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IGF1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IGF1R</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IGF2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IKBKE</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IKZF1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IL10</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IL2RA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IL2RB</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IL2RG</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IL6</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IL7R</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">INHA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">INHBA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">INPP4A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">INPP4B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">INPPL1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">INSR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IRF2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IRF4</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IRS1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">IRS2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ITK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">JAK1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">JAK2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">JAK3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">JUN</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KCNJ5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KDM5A</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KDM5C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KDM6A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KDR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KEAP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KEL</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KIT</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KLF4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KLHL6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KMT2A</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KMT2B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KMT2C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KMT2D</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KNSTRN</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KRAS</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LATS1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LATS2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LCK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LIMK1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LMO1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LRP1B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LTK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LYN</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MALT1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAP2K1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAP2K2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAP2K4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAP2K7</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAP3K1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAP3K13</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAP3K14</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAPK1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAPK3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAPKAP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAX</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MCL1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MDC1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MDM2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MDM4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MED12</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MEF2B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MEN1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MERTK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MET</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MGA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MITF</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MLH1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MPL</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MRE11A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MS4A1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MSH2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MSH3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MSH6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MST1R</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MTOR</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MUTYH</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MYC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MYCL</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MYCN</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MYD88</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MYOD1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NBN</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NCOA3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NCOR1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NEGR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NF1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NF2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NFE2L2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NFKBIA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NKX2-1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NKX3-1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NOTCH1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NOTCH2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NOTCH3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NOTCH4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NPM1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NRAS</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NSD1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NT5C2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NTHL1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NTRK1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NTRK2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NTRK3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NUF2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NUP93</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PAK1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PAK3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PAK7</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PALB2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PARK2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PARP1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PARP2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PAX5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PBRM1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PCBP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PDCD1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PDCD1LG2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PDGFRA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PDGFRB</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PDK1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PDPK1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PGR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PHOX2B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3C2B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3C2G</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3C3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3CA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3CB</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3CD</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3CG</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3R1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3R2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIK3R3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PIM1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PLCG2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PLK2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PMAIP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PMS1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PMS2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PNRC1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">POLD1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">POLE</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PPARG</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PPM1D</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PPP2R1A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PPP2R2A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PPP4R2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PPP6C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PRDM1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PRDM14</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PREX2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PRKAR1A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PRKCI</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PRKD1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTCH1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTEN</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTK6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTP4A1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTPN11</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTPRD</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTPRS</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTPRT</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">QKI</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAB35</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAC1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAC2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAD21</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAD50</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAD51</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAD51B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAD51C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAD51D</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAD52</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAD54L</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAF1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RARA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RASA1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RB1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RBM10</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RECQL</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RECQL4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">REL</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RET</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RFWD2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RHEB</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RHOA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RICTOR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RIT1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RNF43</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ROCK1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ROS1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RPS6KA4</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RPS6KB2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RPTOR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RRAGC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RRAS</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RRAS2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RTEL1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RUNX1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RXRA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RYBP</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SBDS</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SDC4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SDHA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SDHAF2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SDHB</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SDHC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SDHD</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SESN1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SESN2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SESN3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SETD2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SETD8</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SF3B1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SGK1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SH2B3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SH2D1A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SHOC2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SHQ1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SLAMF7</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SLC34A2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SLX4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SMAD2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SMAD3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SMAD4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SMARCA4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SMARCB1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SMARCD1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SMO</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SMYD3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SNCAIP</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SOCS1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SOS1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SOX10</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SOX17</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SOX2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SOX9</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SPEN</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SPOP</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SPRED1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SPRY2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SRC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SRD5A2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SRMS</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SRSF2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">STAG2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">STAT3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">STAT5A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">STAT5B</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">STK11</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">STK19</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">STK40</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SUFU</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SUZ12</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SYK</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TAP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TAP2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TBX3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TCEB1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TCF3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TCF7L2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TEK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TERT</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TET1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TET2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TGFBR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TGFBR2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TIPARP</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TMEM127</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TMPRSS2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TNFAIP3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TNFRSF14</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TNFRSF8</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TNFSF11</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TOP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TP53</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TP53BP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TP63</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TRAF2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TRAF7</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TSC1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TSC2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TSHR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TYRO3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">U2AF1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">UGT1A1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">UPF1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">VEGFA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">VHL</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">VTCN1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">WAS</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">WHSC1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">WHSC1L1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">WISP3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">WT1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">WWTR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">XIAP</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">XPC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">XPO1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">XRCC1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">XRCC2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">YAP1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">YES1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ZFHX3</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ZNF217</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ZNF703</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                </tr>
                            </tbody>
                        </table>
                    </div>
                    <h4 style="font-size: 14px;">45个基因部分外显子（点突变、短片段拆入/缺失、拷贝数变异）</h4>
                    <div style="text-align:center">
                        <table cellspacing="0" cellpadding="0" style="border-collapse:collapse; margin:0 auto; width:100%" border="1">
                            <tbody>
                                <tr>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ABCB1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ABCC2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ABCC4</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ABCG2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ADGRA2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CHST3</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CSNK1A1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP17A1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP1A1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP1B1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP2C19</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DPYD</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DSCAM</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DYNC2H1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ELOC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EMSY</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FANCB</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FCGR3A</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FRK</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GALNT14</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">HDAC1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KAT6A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KMT5A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LRIG3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">LRP2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MAP4K5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MRE11</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MSI1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MTHFR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NOS3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NRG1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NSD2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PAK5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PRKDC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PRKN</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTK2</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RANBP2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RPL13</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RRM1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SIK1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SLC22A2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SLCO1B1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SLCO1B3</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">STAT4</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TYK2</span>
                                        </p>
                                    </td>
                                </tr>
                            </tbody>
                        </table>
                    </div>
                    <h4 style="font-size: 14px;">37个基因部分内含子（融合/重排）</h4>
                    <div style="text-align:center">
                        <table cellspacing="0" cellpadding="0" style="border-collapse:collapse; margin:0 auto; width:100%" border="1">
                            <tbody>
                                <tr>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ALK</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCL2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BCR</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BRAF</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BRCA1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BRCA2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CD74</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERC</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ETV1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ETV4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ETV5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ETV6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EWSR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EZR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGFR1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGFR2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FGFR3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KIT</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">KMT2A</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MET</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MSH2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MYB</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MYC</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NOTCH2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NTRK1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NTRK2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NUTM1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PDGFRA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RAF1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RARA</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RET</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ROS1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RSPO2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SDC4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SLC34A2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TERT</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TMPRSS2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                </tr>
                            </tbody>
                        </table>
                    </div>
                    <h4 style="font-size: 14px;">37个MSI基因</h4>
                    <div style="text-align:center">
                        <table cellspacing="0" cellpadding="0" style="border-collapse:collapse; margin:0 auto; width:100%" border="1">
                            <tbody>
                                <tr>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ACTC</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ATM</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ATM-15</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BAT-25</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BAT-26</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BAT-34c4</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BAT-40</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">BRCA2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CBL-17</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CUL-22</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D10S197</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D17S250</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D17S261</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D17S799</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D18S35</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D18S55</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D18S58</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D1S2883</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D2S123</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">D5S346</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MET</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MITF-14</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MONO-27</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MSH2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MSH6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NF1-26</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NR-21</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NR-22</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NR-24</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NR-27</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PMS2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">POLE</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTK-16</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">PTPN-17</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RET-14</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SDHC</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TGF-βRII</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                </tr>
                            </tbody>
                        </table>
                    </div>
                    <h4 style="font-size: 14px;">41个化疗基因</h4>
                    <div style="text-align:center">
                        <table cellspacing="0" cellpadding="0" style="border-collapse:collapse; margin:0 auto; width:100%" border="1">
                            <tbody>
                                <tr>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ABCB1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ABCG2</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">C8orf34</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CBR3</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CDA</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">COMT</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP19A1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP1B1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-top-color:#3ea6c2; border-top-style:solid; border-top-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP2B6</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP2C19</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP2C8</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP2D6</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP3A4</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP3A5</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP4B1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">CYP4F2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DPYD</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">DYNC2H1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">EGFR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERCC1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">ERCC2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">FASTKD3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GSTM1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GSTP1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">GSTT1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">MTHFR</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NQO1</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NT5C2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">NUDT15</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">RRM1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SEMA3C</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SLC28A3</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SLCO1B1</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">SOD2</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TP53</span>
                                        </p>
                                    </td>
                                    <td style="padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TPMT</span>
                                        </p>
                                    </td>
                                </tr>
                                <tr>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:48.7pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">TYMS</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">UGT1A1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">UMPS</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">XPC</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:9pt; font-style:italic">XRCC1</span>
                                        </p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                    <td
                                        style="border-bottom-color:#3ea6c2; border-bottom-style:solid; border-bottom-width:0.75pt; padding-left:5.4pt; padding-right:5.4pt; vertical-align:middle; width:45.9pt">
                                        <p style="margin:0pt; orphans:0; widows:0"><span
                                                style="font-family:&#39;Times New Roman&#39;; font-size:10.5pt">&nbsp;</span></p>
                                    </td>
                                </tr>
                            </tbody>
                        </table>
                    </div>
                    
                    <div style="text-align: center;background: rgb(65,175,150);color: #fff;line-height: 40px;">肿瘤重要信号通路变异信息汇总</div>

                    <p style="font-weight: bold;font-size: 14px;">评估肿瘤重点信号通路的状态是从全局对癌症进行理解的重要方式。肿瘤相关驱动基因一般都处在肿瘤的重点信号通路上。该样本相关的肿瘤驱动基因变异和非驱动基因变异究竟累及哪些信号通路，信号通路之间各个基因的关系如何，针对相关信号通路的治疗方式以及各个信号通路上下游的信号通路的分布，都能够协助医生和患者理解肿瘤所处状态。</p>

                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);">PI3K/AKT/mTOR信号通路</div>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        PI3K/AKT/MTOR细胞信号通路参与细胞生长增殖，蛋白翻译合成以及调节细胞凋亡。磷酸肌醇3-激酶（PI3K）信号通路可以通过细胞外生长因子（如胰岛素样生长因子IGF1，EGF, HGF等）结合相应的受体酪氨酸激酶或PIK3CA, AKT1, TSC1等基因突变而被激活。PI3K由两个亚基组成：p85和p110。PI3K结合IRS-1激活p110亚基酶活性，活化的PI3K结合细胞膜上的磷脂酰肌醇4,5-二磷酸（PIP2）。PIP2受到催化生成第二信使PIP3激活ATK1，触发下游mTORC1和mTORC2 蛋白复合体从而激活基因转录并促进细胞生长和存活。磷酸酶张力蛋白同系物（PTEN）使磷酸肌醇磷酸盐去磷酸化抑制该通路。
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">上游通路：</text>
                        激酶融合，受体酪氨酸激酶/生长因子信号

                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">下游通路：</text>
                        细胞周期调控

                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路异常激活的疾病：</text>
                        膀胱癌，乳腺癌，肺癌，卵巢癌

                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">靶向通路治疗手段：</text>
                        mTORC1变构抑制剂，mTORC1/2催化抑制剂

                    </p>
                    <div class="imgBox">
                        <img src="./img/680/img11.png" alt="">
                    </div>
                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="10" >PI3K/AKT/mTOR信号通路重点基因变异情况</th>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>AKT1</td>
                                <td>AKT2</td>
                                <td>AKT3</td>
                                <td>CRKL</td>
                                <td>IRS2</td>
                                <td>MTOR</td>
                                <td>PIK3CA</td>
                                <td>PIK3CG</td>
                                <td>PIK3R1</td>
                                <td>PIK3R2</td>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>PTEN</td>
                                <td>RICTOR</td>
                                <td>RPTOR</td>
                                <td>RNF43</td>
                                <td>TSC1</td>
                                <td>TSC2</td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                            </tr>
                        
                        </table>
                    </div>

                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);font-weight: bold;">受体酪氨酸激酶/生长因子信号通路</div>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        受体酪氨酸激酶信号转导调节包括细胞生长，增殖，分化，存活，基因转录和代谢调节等多种细胞过程。生长因子等配体结合受体酪氨酸激酶激活其活性并形成受体二聚体，受体酪氨酸激酶自磷酸化激活包括 MAP激酶信号通路，JAK/STAT信号通路和PI3K/AKT1/MTOR 信号通路等下游途径。复杂的负反馈调节机制减弱活化的受体信号从而抑制受体酪氨酸激酶信号转导。

                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">下游通路：</text>
                        细胞周期调控，JAK/STAT信号通路，PI3K/AKT1/MTOR 信号通路
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路异常激活的疾病：</text>
                        急性粒细胞白血病，间变性大细胞淋巴瘤，乳腺癌，胃癌，胃肠道间质瘤（GIST），肺癌，黑色素瘤，神经母细胞瘤，横纹肌肉瘤，胸腺癌，甲状腺癌
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通靶向通路治疗手段：</text>
                        治疗性抗体，酪氨酸激酶抑制剂
                    </p>
                    <div class="imgBox">
                        <img src="./img/680/img12.png" alt="">
                    </div>
                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="10" >受体酪氨酸激酶/生长因子信号通路重点基因变异情况</th>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>ALK</td>
                                <td>CBL</td>
                                <td>CSF1R</td>
                                <td>DDR2</td>
                                <td style="background: red;color: #fff;">EGFR <br>
                                    突变
                                </td>
                                <td>EPHA3</td>
                                <td>EPHA5</td>
                                <td>EPHB1</td>
                                <td>ERBB2</td>
                                <td>ERBB3</td>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>ERBB4</td>
                                <td>FGF3</td>
                                <td>FGF4</td>
                                <td>FGF6</td>
                                <td>FGF10</td>
                                <td>FGF14</td>
                                <td>FGF19</td>
                                <td>FGF23</td>
                                <td>FGFR1</td>
                                <td>FGFR2</td>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>FGFR3</td>
                                <td>FGFR4</td>
                                <td>FLT1</td>
                                <td>FLT3</td>
                                <td>FLT4</td>
                                <td>HGF</td>
                                <td>IGF1R</td>
                                <td>KIT</td>
                                <td>MET</td>
                                <td>NF1</td>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>NTRK1</td>
                                <td>NTRK2</td>
                                <td>NTRK3</td>
                                <td>PDGFRA</td>
                                <td>PDGFRB</td>
                                <td>PTPN11</td>
                                <td>RET</td>
                                <td>ROS1</td>
                                <td></td>
                                <td></td>
                            </tr>
                        
                        </table>
                    </div>
                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);font-weight: bold;">细胞凋亡信号通路</div>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        细胞凋亡途径是细胞程序性死亡的一种，包括外在途径和内在途径。外在途径是由细胞外事件触发的，FAS配体(FASLG)结合细胞表面FAS受体所介导的。内在途径是由如细胞毒素、病毒感染、自由基、辐射或是DNA损伤等引起的细胞内应激所触发的，通过线粒体的BCL-2家族蛋白激活内在途径。线粒体激活可以释放促凋亡蛋白进入细胞质中激活caspase从而引起细胞死亡。细胞内外途径都引起caspase级联反应，引起细胞死亡或是凋亡，从而影响包括肿瘤在内的疾病进程。
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">上游通路：</text>
                        受体酪氨酸激酶/生长因子信号，MAP激酶信号通路，JAK/STAT信号通路，PI3K/AKT1/MTOR信号通路，DNA损伤/修复，细胞周期调控
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">下游通路：</text>
                        蛋白质降解/泛素化
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">靶向通路治疗手段：</text>
                        BCL2抑制剂
                    </p>

                    <div class="imgBox">
                        <img src="./img/680/img13.png" alt="">
                    </div>
                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="10" >细胞凋亡信号通路重点基因变异情况</th>
                            </tr>
                            
                            <tr style="text-align: center;line-height: 30px;">
                                <td>APAF1</td>
                                <td>BAK1</td>
                                <td>BAX</td>
                                <td>BCL2</td>
                                <td>BID</td>
                                <td>CASP3</td>
                                <td>CASP8</td>
                                <td>CASP9</td>
                                <td>FAS</td>
                                <td>FASLG</td>
                            </tr>
                            
                        </table>
                    </div>
                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);font-weight: bold;">细胞周期调控信号通路</div>

                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        细胞周期调控参与细胞的生长、复制和分裂，包括四个阶段：G1期（DNA合成前期）、S期（DNA合成期）、G2期（DNA合成后期）和M期（有丝分裂期）。细胞周期调控取决于特定的细胞周期检查点，这些检查点可以防止异常的细胞周期激活和继续，确保子代细胞的完整性。例如：G2/M期检查点阻止含有异常DNA的细胞进入有丝分裂期。细胞检查点包括G1/S期和G2/M期检查点等，这些周期检查点由CDK（CDK -1, -2, -4, -6, -8, -12）和cyclin（cyclin -A, -B, -D, -E）复合物协调控制，如：CDK4/6+cyclin D, RB1/E2F, CDK2+cyclin E, CDK2+cyclin A, CDK1+cyclin A, CDK1+cyclin B等。细胞检查点在应对DNA损伤中发挥着重要作用。DNA损伤激活这些检查点，通过修复损伤的DNA或在DNA损伤不能修复的情况下细胞进入程序性死亡以确保基因组完整性。检查点和DNA损伤修复反应在许多肿瘤中发生了改变。
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">上游通路：</text>
                        JAK/STAT信号通路，激酶融合，MAP激酶信号通路，PI3K/AKT1/MTOR信号通路，受体酪氨酸激酶/生长因子信号
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路异常激活的疾病：</text>
                        急性粒细胞白血病，膀胱癌，乳腺癌，骨髓增生异常综合征
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">靶向通路治疗手段：</text>
                        CDK抑制剂，CDK1抑制剂，CDK2抑制剂，CDK4/6抑制剂
                    </p>
                    <div class="imgBox">
                        <img src="./img/680/img14.png" alt="">
                    </div>
                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="10" >细胞周期调控信号通路重点基因变异情况</th>
                            </tr>
                            
                            <tr style="text-align: center;line-height: 30px;">
                                <td>AURKA</td>
                                <td>AURKB</td>
                                <td>CCND1</td>
                                <td>CCND2</td>
                                <td>CCND3</td>
                                <td>CDK1</td>
                                <td>CDK2</td>
                                <td>CDK3</td>
                                <td>CDK4</td>
                                <td>CDK6</td>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>CDK8</td>
                                <td>CDK12</td>
                                <td>CDKN1B</td>
                                <td>CDKN2A</td>
                                <td>CDKN2B</td>
                                <td>CDKN2C</td>
                                <td>CHEK1</td>
                                <td>CHEK2</td>
                                <td>CCNA1</td>
                                <td>CCNA2</td>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>CCNB1</td>
                                <td>CCNB2</td>
                                <td>CCNB3</td>
                                <td>CCNE1</td>
                                <td>CCNE2</td>
                                <td>E2F1</td>
                                <td>C11orf30 (EMSY)</td>
                                <td>RB1</td>
                                <td style="background: red;color: #fff;">TP53 <br>
                                    突变
                                </td>
                                <td></td>
                            </tr>
                            
                        </table>
                    </div>
                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);font-weight: bold;">代谢通路</div>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        CDK抑制剂，CDK1抑制剂，CDK2抑制剂，CDK4/6抑制剂
                    </p>
                   
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路异常激活的疾病：</text>
                        急性粒细胞白血病，胶质瘤
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">靶向通路治疗手段：</text>
                        IDH1抑制剂
                    </p>

                    <div class="imgBox">
                        <img src="./img/680/img15.png" alt="">
                    </div>

                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="10" >代谢通路重点基因变异情况</th>
                            </tr>
                            
                            <tr style="text-align: center;line-height: 30px;">
                                <td>ACO1</td>
                                <td>ACO2</td>
                                <td>CS</td>
                                <td>FH</td>
                                <td>IDH1</td>
                                <td>IDH2</td>
                                <td>LDHA</td>
                                <td>LDHB</td>
                                <td>MDH2</td>
                                <td>OGDH</td>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>PC</td>
                                <td>PDHA1</td>
                                <td>PDHB</td>
                                <td>PKM</td>
                                <td>SUCLA2</td>
                                <td>SUCLG1</td>
                                <td>SUCLG2</td>
                                <td></td>
                                <td></td>
                                <td></td>
                            </tr>
                            
                        </table>
                    </div>
                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);font-weight: bold;">WNT/ß-catenin信号通路</div>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        β-Catenin/WNT信号通路调控基因表达，促进细胞的生长和存活。该信号通路由WNT1配体和G蛋白偶联受体FZD1结合激活，当缺乏WNT1配体时该信号通路被阻断。WNT1配体存在时，DVL1促进破坏复合物（destruction complex）的解离，导致细胞内β-Catenin水平升高从而进入核内调控基因表达促进细胞生长和存活。当WNT1信号缺失，BTRC结合β-Catenin使其泛素化，在蛋白酶体中降解。低水平的β-Catenin阻断基因表达，细胞生长和存活途径。肿瘤细胞中引发β-Catenin泛素化的蛋白常常突变，导致细胞内β-Catenin水平升高从而造成细胞生长和增殖失控。
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">下游途径：</text>
                        细胞周期调控
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路异常激活的疾病：</text>
                        结直肠癌和黑色素瘤
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">靶向通路治疗手段：</text>
                        FZD抑制剂，GSK抑制剂
                    </p>
                    <div class="imgBox">
                        <img src="./img/680/img16.png" alt="">
                    </div>

                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="10" >WNT/ß-catenin信号通路重点基因变异情况</th>
                            </tr>
                            
                            <tr style="text-align: center;line-height: 30px;">
                                <td>APC</td>
                                <td>AXIN1</td>
                                <td>BTRC</td>
                                <td>CSNK1A1</td>
                                <td>CTNNA1</td>
                                <td style="background: red;">CTNNB1 <br>
                                    突变</td>
                                <td>DVL1</td>
                                <td>FZD1</td>
                                <td>GSK3B</td>
                                <td>LRP5</td>
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>LRP6</td>
                                <td>WISP3</td>
                                <td>WNT1</td>
                                <td>WT1</td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                            </tr>
                            
                        </table>
                    </div>

                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);font-weight: bold;">Hedgeho信号通路</div>

                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        hedgehog (Hh)细胞信号通路在胚胎发育期间促进细胞生长和发育，但在癌症中也常常异常激活。hedgehog配体（sonic, desert, indian）结合细胞膜上的PTCH1激活Hh信号通路，在没有配体的情况下，hedgehog信号通路被PTCH1阻滞，PTCH1通过维持SMO在细胞囊泡内抑制SMO的活化。当PTCH1结合hedgehog配体，PTCH1从SMO解离内化并被降解，SMO迁移转位到细胞表面并启动hedgehog信号通路。SMO的激活触发基因转录，正常胚胎发育，细胞生长和存活。
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">下游通路：</text>
                        细胞周期调控
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路异常激活的疾病：</text>
                        基底细胞癌，髓母细胞瘤
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">靶向通路治疗手段：</text>
                        SMO抑制剂
                    </p>
                    <div class="imgBox">
                        <img src="./img/680/img17.png" alt="">
                    </div>
                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="3" >Hedgeho信号通路重点基因变异情况</th>
                            </tr>
                            
                            <tr style="text-align: center;line-height: 30px;">
                                <td>PTCH1</td>
                                <td>SMO</td>
                                <td>SUFU</td>
                                
                            </tr>
                            
                            
                        </table>
                    </div>

                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);font-weight: bold;">TGFβ信号通路</div>

                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        SMO抑制剂转化生长因子-β（TGFB1）信号通路在癌症发生进展和转移中有着复杂的作用。TGFB1配体二聚体与TGF-βⅡ型受体(TGFBR2)结合促进TGFBR2和TGFBR1二聚体化后磷酸化TGFBR1激活TGFB1信号通路。活化的TGFB1磷酸化R-SMADs（SMAD2和SMAD3），SMAD2、SMAD3与SMAD4形成SMAD三聚体。SMAD三聚体进入细胞核激活基因转录促进细胞生长和存活。
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">下游通路：</text>
                        细胞周期调控
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路异常激活的疾病：</text>
                        结直肠癌，多形性胶质母细胞瘤和胰腺癌
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">靶向通路治疗手段：</text>
                        TGFBR1抑制剂
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路涉及的基因：</text>
                        SMAD2, SMAD3, SMAD4, TGFB1, TGFBR1, TGFBR2, TGFBR3
                    </p>
                    <div class="imgBox">
                        <img src="./img/680/img18.png" alt="">
                    </div>
                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="7" >TGFβ信号通路重点基因变异情况</th>
                            </tr>
                            
                            <tr style="text-align: center;line-height: 30px;">
                                <td>SMAD2</td>
                                <td>SMAD3</td>
                                <td>SMAD4</td>
                                <td>TGFB1</td>
                                <td>TGFBR1</td>
                                <td>TGFBR2</td>
                                <td>TGFBR3</td>
                                
                            </tr>
                            
                            
                        </table>
                    </div>

                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);font-weight: bold;">JAK/STAT信号通路</div>
                    
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        JAK/STAT细胞信号通路参与基因转录和免疫调节。细胞内酪氨酸激酶JAK1/2/3，转录因子STAT 1/2/3共同调控基因表达。白细胞介素，干扰素或生长因子等配体结合细胞表面特异抗体通过JAK/STAT通路向下游传递信号。具体过程：酪氨酸激酶受体促进JAK1/2/3活化，JAK1/2/3自磷酸化后招募STAT-1/-2/-3/-4/-5/-6信号转导子和转录激活子。磷酸化的STAT形成蛋白二聚体进入细胞核内结合DNA激活基因转录，调节免疫促进细胞生长和存活。
                    </p>

                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">上游通路：</text>
                        激酶融合，受体酪氨酸激酶/生长因子信号
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">下游通路：</text>
                        细胞周期调控
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路异常激活的疾病：</text>
                        急性淋巴细胞白血病，慢性粒细胞白血病
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">靶向通路治疗手段：</text>
                        JAK抑制剂
                    </p>
                    
                    <div class="imgBox">
                        <img src="./img/680/img19.png" alt="">
                    </div>
                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="10" >JAK/STAT信号通路重点基因变异情况</th>
                            </tr>
                            
                            <tr style="text-align: center;line-height: 30px;">
                                <td>CRLF2</td>
                                <td>JAK1</td>
                                <td>JAK2</td>
                                <td>JAK3</td>
                                <td>SOCS1</td>
                                <td>STAT1</td>
                                <td>STAT2</td>
                                <td>STAT3</td>
                                <td>STAT4</td>
                                <td>STAT5A</td>
                                
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>STAT5B</td>
                                <td>STAT6</td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                              
                                
                            </tr>
                            
                            
                        </table>
                    </div>

                    <div style="text-align: center;line-height: 30px;background: rgb(182, 232, 239);font-weight: bold;">激酶融合信号通路</div>
                    
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路简介：</text>
                        激酶融合信号参与基因转录、细胞生长、增殖、分化、存活和代谢调控。两个基因易位重排（其中一个基因编码蛋白激酶）导致融合激酶产生；肿瘤细胞中异常基因组改变常导致融合激酶的产生。激酶融合后激活如MAP激酶信号传导，JAK/STAT信号传导和PI3K/AKT/MTOR信号传导等下游信号传导途径从而促进基因转录，细胞生长，增殖，分化和存活。
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">上游通路：</text>
                        受体酪氨酸激酶/生长因子信号
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">下游通路：</text>
                        细胞周期调控，MAP激酶信号传导，JAK/STAT信号，PI3K/ AKT1/ MTOR信号
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">通路异常激活的疾病：</text>
                        间变性大细胞淋巴瘤，慢性粒细胞白血病，炎性肌纤维母细胞瘤，肺癌
                    </p>
                    <p style="font-size:14px">
                        <text style="font-weight: bold;font-size: 12px;">靶向通路治疗手段：</text>
                        JAK抑制剂，ABL抑制剂，ALK抑制剂，FGFR1 / 2/3抑制剂。NTRK1 / 2/3抑制剂，RET抑制剂，ROS1抑制剂
                    </p>

                    <div class="imgBox">
                        <img src="./img/680/img20.png" alt="">
                    </div>

                    <div class="table-680-1" style="width: 100%;">
                        <table border="1" style="width: 100%;">
                            <tr style="line-height: 30px;color: #fff;background: rgb(166,166,166);">
                                <th colspan="10" >激酶融合信号通路重点基因变异情况</th>
                            </tr>
                            
                            <tr style="text-align: center;line-height: 30px;">
                                <td>BRAF</td>
                                <td>ABL1</td>
                                <td>ALK</td>
                                <td>FGFR1</td>
                                <td>FGFR2</td>
                                <td>FGFR3</td>
                                <td>NTRK1</td>
                                <td>NTRK2</td>
                                <td>NTRK3</td>
                                <td>TRET</td>
                                
                            </tr>
                            <tr style="text-align: center;line-height: 30px;">
                                <td>ROS1</td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                                <td></td>
                              
                                
                            </tr>
                            
                            
                        </table>
                    </div>


                </div>
            </section>

            <section class="main-part part7">
                <h3>·参考文献</h3>
                <div style="font-size: 14px;">
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                   <p>125. PMID: 29337640 Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.</p>
                   <p>126. 2019 ASCO Abstract 9082 Impact of KRAS allele subtypes and concurrent genomic alterations on clinical outcomes to programmed death 1 axis blockade in non-small cell lung cancer.</p>
                   <p>127. 2018 IASLC Abstract MA19.09 Concurrent Mutations in STK11 and KEAP1 is Associated with Resistance to PD-(L)1 Blockade in Patients with NSCLC Despite High TMB.</p>
                   <p> 128. 2019 ASCO Abstract 4036 Association of frequent amplification of chromosome 11q13 in esophageal squamous cell cancer with clinical benefit to immune check point blockade.</p>
                   <p>129. 2017 ESMO Abstract 1140PD Predictive biomarkers for Hyper-progression (HP) in response to Immune Checkpoint Inhibitors (ICI) – Analysis of Somatic Alterations (SAs).</p>
                   <p>130. PMID: 29056344 Comprehensive Analysis of Hypermutation in Human Cancer.</p>
                   <p>131. NCT03150706 Avelumab for MSI-H or POLE Mutated Metastatic Colorectal Cancer</p>
                   <p>132. NCT03461952 Nivolumab Ipilimumab in Patients With hyperMutated Cancers Detected in Blood (NIMBLe)</p>
                   <p>133. PMID: 28188185 Response to PD-1 Blockade in Microsatellite Stable Metastatic Colorectal Cancer Harboring a POLE Mutation.</p>
                   <p> 134. NCT03491345 K-Basket, Avelumab, Biomarker-driven, Advanced Solid Tumor.</p>
                   <p>135. PMID: 26645196 Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.</p>
                   <p> 136. PMID: 28228279 Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma.</p>
                   <p>137. PMID: 28167612 JAK Mutations as Escape Mechanisms to Anti-PD-1 Therapy.</p>
                   <p>138. PMID: 27433843 Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.</p>
                   <p>139. PMID: 27903500 Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.</p>
                   <p>140. PMID: 22137796 Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma.</p>
                   <p>141. PMID: 29070816 Resistance to checkpoint blockade therapy through inactivation of antigen presentation.</p>
                   <p> 142. PMID: 27225694 EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer: A Retrospective Analysis.</p>
                   <p> 143. PMID: 26069186 Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.</p>
                   <p>144. PMID: 26833127 STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.</p>
                   <p>145. PMID: 1614537 Amplification of a gene encoding a p53-associated protein in human sarcomas.</p>
                   <p>146. PMID: 16905769 Hdmx modulates the outcome of p53 activation in human tumor cells.</p>
                   <p>147. PMID: 27827313 Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1.</p>
                   <p>148. PMID: 28351930 Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate.</p>
                   <p>149. PMID: 26858935 Clinical Overview of MDM2/X-Targeted Therapies.</p>
                   <p>150. PMID: 16354690 Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.</p>
                   <p>151. PMID: 10555141 DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.</p>
                   <p>152. PMID: 29414941 Structural basis for DNMT3A-mediated de novo DNA methylation.</p>
                   <p> 153. PMID: 28976787 Negative predictive biomarkers of checkpoint inhibitors in hyper-progressive tumors.</p>
                   <p>154. PMID: 29217585 Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy.</p>
                
                
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